UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 14A
Proxy Statement Pursuant to Section 14(a) of the
Securities Exchange Act of 1934 (Amendment No. __)


Filed by the Registrant x Filed by a Party other than the Registrant ¨
Filed by the RegistrantýFiled by a Party other than the Registrant¨
Check the appropriate box:
¨ýPreliminary Proxy Statement
¨Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2))
x¨Definitive Proxy Statement
¨Definitive Additional Materials
¨Soliciting Material under §240.14a-12

CONCERT PHARMACEUTICALS, INC.
(Exact nameName of registrantRegistrant as specifiedSpecified in its charter)Charter)

(Name of Person(s) Filing Proxy Statement, if other thanOther Than the Registrant)
Payment of Filing Fee (Check the appropriate box)all boxes that apply):
xýNo fee required.
¨Fee paid previously with preliminary materials.
¨Fee computed on table belowin exhibit required by Item 25(b) per Exchange Act Rules 14a-6(i)(1) and 0-11.
(1)
Title of each class of securities to which transaction applies:
(2)
Aggregate number of securities to which transaction applies:
(3)
Per unit price or other underlying value of transaction computed pursuant to Exchange Act Rule 0-11 (set forth the amount on which the filing fee is calculated and state how it was determined):
(4)
Proposed maximum aggregate value of transaction:
(5)
Total fee paid:
¨Fee paid previously with preliminary materials.
¨Check box if any part of the fee is offset as provided by Exchange Act Rule 0-11(a)(2) and identify the filing for which the offsetting fee was paid previously. Identify the previous filing by registration statement number, or the Form or Schedule and the date of its filing.
(1)
Amount Previously Paid: $0
(2)
Form, Schedule or Registration Statement No.: Schedule 14A
(3)
Filing Party: Concert Pharmaceuticals, Inc.
(4)
Date Filed:






image_0.jpg
NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
Toto be held on Thursday, June 13, 20199, 2022

Dear Stockholders,
You are cordially invited to attend the 20192022 annual meeting of stockholders (the “Annual Meeting”) of Concert Pharmaceuticals, Inc. (the(“we” orCompanyus”), which will be held on Thursday, June 13, 20199, 2022 at 9:00 AMa.m., Eastern Time,time, at theour offices, of the Company, 65 Hayden Avenue, Suite 3000N, Lexington, MA 02421, to consider and vote upon the following proposals:
1. The election of twoTo elect one Class II Directors (the “Director Nominees”) to our Board of Directors (the(ourBoard”), to serve until the 2022our 2025 annual meeting of stockholders (the “Director Proposal”);stockholders;
2. The ratification ofTo hold a non-binding, advisory vote on executive compensation;
3. To ratify the appointment of Ernst & Young LLP as our independent registered public accounting firm for the fiscal year ending December 31, 20192022;
4. To approve an amendment to our restated certificate of incorporation, as amended (the “Auditor Proposalcertificate of incorporation”); to increase the number of authorized shares of common stock from 100,000,000 to 200,000,000; and
3. Transaction of5. To transact any other business properly brought before the Annual Meeting or any adjournment or postponement of the Annual Meeting.
Our Board has fixed the close of business on April 16, 201912, 2022 as the record date for the purposepurposes of determining the stockholders who are entitled to receive notice of, and to vote at, the Annual Meeting. Only stockholders of record at the close of business on the record date are entitled to notice of, and to vote at, the Annual Meeting and at any adjournmentadjournments or postponements of that meeting.the Annual Meeting.
We are pleased to take advantage of Securities and Exchange Commission rules that allow companies to furnish their proxy materials over the Internet. On or about May 3, 2019,[_____], 2022, we are mailing to many of our stockholders a Notice of Internet Availability of Proxy Materials (the “Notice”) instead of a paper copy of our proxy materials and our 20182021 Annual Report on Form 10-K. The Notice contains instructions on how to access those documents and to cast your vote via the Internet or by telephone. The Notice also contains instructions on how to request a paper copy of our proxy materials and our 20182021 Annual Report on Form 10-K. All stockholders who do not receive a Notice will receive a paper copy of the proxy materials and the 20182021 Annual Report on Form 10-K by mail. This process allows us to provide our stockholders with the information they need on a more timely basis, while reducingreduce the environmental impact and loweringlower the costs of printing and distributing our proxy materials.
Your vote is very important. Whether or not you plan to attend the Annual Meeting in person, please vote as soon as possible by submitting your proxy via the Internet or by telephone as indicated on theyour proxy card or in your proxy materials or by signing, dating and returning the proxy card. If you hold your shares in “street name,” you should instruct your bank, broker or other nominee on how to vote your shares in accordance with the voting instruction form that you will receive from your bank, broker or other nominee.

We currently intend to hold the Annual Meeting in person. However, we are continuing to monitor the ongoing coronavirus (COVID-19) pandemic and are sensitive to the public health and travel concerns our stockholders may have and the protocols that federal, state and local governments may impose. In the event it is not possible or advisable to hold the Annual Meeting in person, we will announce alternative arrangements for the meeting as promptly as practicable, which may include holding the meeting solely by means of remote communication. Please monitor the “Investors” section of our website,



www.concertpharma.com, for updated information. If you are planning to attend the Annual Meeting, please check the website one week prior to the meeting date. As always, we encourage you to vote your shares prior to the Annual Meeting.

    By Order of the Board of Directors
    Roger D. Tung, Ph.D.
    President and Chief Executive Officer
Lexington, Massachusetts
[_____], 2022



image_0.jpg
PROXY STATEMENT
FOR ANNUAL MEETING OF STOCKHOLDERS
to be held on Thursday, June 9, 2022


BY ORDER OF THE BOARD OF DIRECTORS
/s/ Roger D. Tung
Roger D. Tung, Ph.D.
President andChief Executive Officer







QUESTIONS AND ANSWERS ABOUT THE ANNUAL MEETING AND THE PROPOSALS
The following are some questions that you, as a holder of common stock of the Company,Concert Pharmaceuticals, Inc. (“Concert,” “we” or “us”) may have regarding the 2019our 2022 annual meeting of stockholders (the “Annual Meeting”) of Concert Pharmaceuticals, Inc. (the “Company”) and the proposals and brief answers to such questions. We urge you to carefully read this entire proxy statement and the documents referred to in this proxy statement because the information in this section does not provide all the information that may be important to you as a stockholder of the CompanyConcert with respect to the proposals.
Our Board of Directors (the “Board of Directors” or the(ourBoard”) has made this proxy statement and related materials available to you on the Internet, or at your request has delivered printed versions to you by mail, in connection with the solicitation of proxies by theour Board of Directors for the Annual Meeting, and any adjournment or postponement of the Annual Meeting. If you requested printed versions of these materials by mail, they will also include a proxy card for the Annual Meeting.card.
Pursuant to rules adopted by the Securities and Exchange Commission (the “SEC”), we are providing access to our proxy materials over the Internet. Accordingly, we are sending a Notice of Internet Availability of Proxy Materials (the “Notice”) to our stockholders of record and beneficial owners as of the record date identified below.April 12, 2022 (the “Record Date”). The mailing of the Notice to our stockholders is scheduled to begin on or about May 3, 2019.[_____], 2022.
IMPORTANT NOTICE REGARDING THE INTERNET AVAILABILITY OF PROXY MATERIALS FOR THE ANNUAL STOCKHOLDERS MEETING TO BE HELD ON JUNE 13, 2019:9, 2022:
This Proxy Statement, the accompanying proxy card or voting instruction card and our 20182021 Annual Report on Form 10-K are available at: http://ir.concertpharma.com/annual-meeting.
In this proxy statement,on the terms “we,” “us,” “our,” “the Company” and “Concert” refer to Concert Pharmaceuticals, Inc.



THE ANNUAL MEETING“Investors” section of our website, www.concertpharma.com.
When and where will the Annual Meeting take place?
The Annual Meeting will be held on June 13, 20199, 2022 at 9:00 AMa.m., Eastern Time,time, at theour offices, of the Company, 65 Hayden Avenue, Suite 3000N, Lexington, MA 02421.
Will the Annual Meeting be impacted by the ongoing coronavirus (COVID-19) pandemic?
We are continuing to monitor the ongoing coronavirus (COVID-19) pandemic and are sensitive to the public health and travel concerns our stockholders may have and the protocols that federal, state and local governments may impose. In the event it is not possible or advisable to hold the Annual Meeting in person, we will announce alternative arrangements for the meeting as promptly as practicable, which may include holding the meeting solely by means of remote communication. Please monitor the “Investors” section of our website, www.concertpharma.com, for updated information. If you are planning to attend the Annual Meeting, please check the website one week prior to the meeting date. As always, whether or not you plan to attend the Annual Meeting in person, please vote as soon as possible by submitting your proxy via the Internet or by telephone as indicated on the proxy card or by signing, dating and returning the proxy card.
What proposals are the stockholders being asked to consider?
At the Annual Meeting, you will be asked to consider and vote upon:upon the following proposals:

1.
The election of twoTo elect one Class II DirectorsDirector (the “Director NomineesNominee”) to our Board, to serve until the 2022our 2025 annual meeting of stockholders (the “Director Proposal”);
2.
The ratification ofTo hold a non-binding, advisory vote on executive compensation (the “Say-on-Pay Proposal”);
3.
To ratify the appointment of Ernst & Young LLP as our independent registered public accounting firm for the fiscal year ending December 31, 20192022 (the “Auditor Proposal”);
4.
To approve an amendment to our certificate of incorporation to increase the number of authorized shares of common stock from 100,000,000 to 200,000,000 (the “Authorized Shares Proposal”); and
5.
3.Transaction ofTo transact any other business properly brought before the Annual Meeting or any adjournment or postponement of the Annual Meeting.

1


What are the recommendations of theour Board?
TheOur Board unanimously recommends that the stockholders vote “FOReach of the Director NomineesNominee, the Say-on-Pay Proposal, the Auditor Proposal and the AuditorAuthorized Shares Proposal.
What is the Record Date for the Annual Meeting?
Holders of our common stock as of the close of business on April 16, 2019, the “Record Date” for the Annual Meeting,12, 2022 are entitled to notice of, and to vote at, the Annual Meeting and any postponementsadjournments or adjournmentspostponements of the Annual Meeting.
Who can vote at the Annual Meeting?
Stockholders who owned shares of our common stock on the Record Date may attend and vote at the Annual Meeting. There were 23,781,68736,329,342 shares of common stock outstanding on the Record Date. All shares of common stock have one vote per share and vote together as a single class. Information about the stockholdings of our directors and executive officers is contained in the section of this proxy statement entitled “Principal StockholdersStock Ownership and Reporting – Security Ownership of Certain Beneficial Owners and Management..
What is the proxy card?
The proxy card enables you to appoint Roger D. Tung and Marc Becker as your proxies at the Annual Meeting. By completing and returning or submitting the proxy card as described herein or in the Notice, you are authorizing these people to vote your shares at the Annual Meeting in accordance with your instructions on the proxy card. This way, your shares will be voted whether or not you attend the Annual Meeting. Even if you plan to attend the Annual Meeting, we think that it is a good idea to complete and return or submit your proxy card before the Annual Meeting date just in case your plans change. If a proposal comes up for vote at the Annual Meeting that is not on the proxy card, the proxies will vote your shares, under your proxy, according to their best judgment.
What is the difference between holding shares as a stockholder of record and as a beneficial owner?
Most of our stockholders hold their shares in an account at a brokerage firm, bank or other nominee holder, rather than holding share certificates in their own name. As summarized below, there are some distinctions between shares held of record and those owned beneficially.
Stockholder of Record
If, on the Record Date, your shares were registered directly in your name with our transfer agent, Computershare, you are a “stockholder of record” who may vote at the Annual Meeting, and we are sending these proxy materials or the Notice directly to you. You can vote by proxy overvia the Internet or by telephone by following the instructions provided in the Notice, or, if you

requested printed copies of the proxy materials by mail, you can vote by mailing your proxy as described in the proxy materials.
Beneficial Owner
If, on the Record Date, your shares were held in an account at a brokerage firm or at a bank or other nominee holder, you are considered the beneficial owner of shares held “in streetin “street name,” and these proxy materials or the Notice are being forwarded to you by your broker, bank or other nominee who is considered the stockholder of record for purposes of voting at the Annual Meeting. As the beneficial owner, you have the right to direct your broker, bank or other nominee on how to vote your shares and to attend the Annual Meeting. However, since you are not the stockholder of record, you may not vote these shares in person at the Annual Meeting unless you receive a valid proxy from your brokerage firm, bank or other nominee holder. To obtain a valid proxy, you must make a special request of your brokerage firm, bank or other nominee holder. If you do not make this request, you can still vote by using the voting instruction card enclosed with this proxy statement; however, you will not be able to vote in person at the Annual Meeting.
What is the quorum required for the Annual Meeting?
The representation in person or by proxy of holders of at least a majority of the issued and outstanding shares of our common stock entitled to vote at the Annual Meeting is necessary to constitute a quorum for the transaction of business at the Annual Meeting. For purposes of determining the presence of a quorum, abstentions and broker non-votes will be counted as present at the Annual Meeting.
2


Assuming that a quorum is present, what vote is required to approve the proposals to be voted upon at the Annual Meeting?
Director Proposal: The election of the Director Nominee requires a plurality of the affirmative votes cast at the Annual Meeting. You may vote “For” or “Withhold” your vote.
Say-on-Pay Proposal:The electionapproval of each Director Nomineethis proposal requires the affirmative vote of a plurality of votesmajority of the sharesvotes cast affirmatively or negatively at the Annual Meeting. Because the Say-on-Pay Proposal is advisory, it will not be binding on Concert, our Board or any committee of our Board. However, our Board, including our compensation committee, values the opinions of our stockholders and, to the extent there are a substantial number of votes cast against the executive officer compensation as disclosed in this proxy statement, we will consider our stockholders’ concerns and evaluate what actions may be appropriate to address those concerns. You may vote “For” or “Against” or abstain from voting on the Say-on-Pay Proposal.

Auditor Proposal: The ratification of the appointment of Ernst & Young LLP requires the affirmative vote of a majority of the shares present in personvotes cast affirmatively or represented by proxynegatively at the Annual Meeting. You may vote “For” or “Against” or abstain from voting on the Auditor Proposal.

Authorized Shares Proposal: The affirmative vote of the holders of a majority of the shares of our common stock issued and outstanding and entitled to vote at the Annual Meeting is required for approval of the amendment to our certificate of incorporation to increase the number of authorized shares of common stock.You may vote “For” or “Against” or abstain from voting on the Authorized Shares Proposal.
How do I vote?
Stockholders have four voting options. You may vote using one of the following methods:
1.
Internet or Telephone. To vote byvia the Internet or by telephone, please follow the instructions shown on the Notice.
2.
Mail. If you requested or receive a paper proxy card and voting instructions by mail, simply complete, sign and date the enclosed proxy card and return it before the meetingAnnual Meeting in the envelope provided.
3.
In Person. You may come to the Annual Meeting and cast your vote there. The Board recommendsWe recommend that you vote by proxy even if you plan to attend the Annual Meeting. If your shares of common stock are held in a stock brokerage account or through a bank, broker or other nominee, or, in other words, in “street name”,street name, and you wish to vote in person at the Annual Meeting, you must bring a letter from your bank, broker or nominee identifying you as the beneficial owner of the shares and authorizing you to vote such shares at the Annual Meeting. Please see the question above regarding the coronavirus (COVID-19) pandemic should alternative arrangements be required.

TelephoneInternet and Internettelephone voting for stockholders of record will be available up until 11:59 p.m., Eastern Timetime, on June 12, 2019,8, 2022, and mailed proxy cards must be received by June 12, 20198, 2022 in order to be counted at the Annual Meeting. If the Annual Meeting is adjourned or postponed, these deadlines may be extended.

The voting deadlines and availability of telephoneInternet and Internettelephone voting for beneficial owners of shares held in “street name”street name will depend on the voting processes of the organization that holds your shares. Therefore, we urge you to carefully review and follow the voting instruction card and any other materials that you receive from that organization.
What are the effects of not voting or abstaining? What are the effects of broker non-votes?
If you do not vote by virtue of not being present in person or by proxy at the Annual Meeting, your shares will not be counted for purposes of determining the existence of a quorum.

Abstentions will be counted for the purposepurposes of determining the existence of a quorum. However, they will not be considered in determining the number of votes cast. Accordingly, an abstention will have no effect on the Director Proposal or the Auditor Proposal.
3


Broker non-votes occur on a matter when a broker is not permitted to vote on that matter without instructions from the beneficial owner and instructions are not given. These matters are referred to as “non-routine”considered non-discretionary matters. Broker non-votes will be counted for the purposepurposes of determining the existence of a quorum. The Director Proposal is a “non-routine” matter.and the Say-on-Pay Proposal are non-discretionary matters. Thus, in tabulating the voting resultresults for the Director Proposal and the Say-on-Pay Proposal, shares that constitute broker non-votes are not considered votes cast on the Director Proposal.such proposals. The Auditor Proposal isand the Authorized Shares Proposal are considered a “routine” matterdiscretionary matters, and a broker or other nominee may generally exercise discretionary authority to vote on such proposals.

The following table summarizes the minimum vote needed to approve each proposal and the effect of abstentions and broker non-votes.
Proposal NumberProposal DescriptionVote Required for ApprovalEffect of AbstentionsEffect of Broker Non-Votes
1Director ProposalPluralityNo effectNo effect
2Say-on-Pay ProposalMajority of the votes cast affirmatively or negativelyNo effectNo effect
3Auditor ProposalMajority of the votes cast affirmatively or negativelyNo effect
Not applicable (1)
4Authorized Shares ProposalMajority of the shares of our common stock issued and outstanding and entitled to vote at the Annual MeetingAgainst
Not applicable (1)
(1) We expect that there will be no broker non-votes with respect to the Auditor Proposal.Proposal and the Authorized Shares Proposal because brokers have discretionary voting authority with respect to these proposals.
What does it mean if I received more than one proxy card or Notice?
If your shares are registered differently or in more than one account, you will receive more than one proxy card or Notice. To make certain all of your shares are voted, please follow the instructions included on the Notice on how to access each proxy card and vote each proxy card via the Internet or by telephone or through the Internet.telephone. If you requested or received paper proxy materials by mail, please complete, sign and return each proxy card to ensure that all of your shares are voted.
What happens if I don’t indicate how to vote my proxy?
If you just sign or submit your proxy card without providing further instructions, your shares will be counted as a vote “for” each of“FOR” the Director NomineesNominee, the Say-on-Pay Proposal, the Auditor Proposal and the AuditorAuthorized Shares Proposal.
What happens if I sell my shares after the record dateRecord Date but before the Annual Meeting?
If you transfer your shares after the Record Date but before the date of the Annual Meeting, you will retain your right to vote at the Annual Meeting (provided that such shares remain outstanding on the date of the Annual Meeting).
What if I change my mind after I return my proxy?
You may revoke your proxy and change your vote at any time before the polls close at the Annual Meeting. You may do this by:
sending a written notice to our Corporate Secretary atConcert Pharmaceuticals, Inc., 65 Hayden Avenue, Suite 3000N, Lexington, MA 02421, Attention: Corporate Secretary stating that you would like to revoke your proxy of a particular date;
voting again at a later time, but prior to the date of the Annual Meeting, via the Internet or by telephone;
signing or submitting another proxy card with a later date and returning it before the polls close at the Annual Meeting; or
attending the Annual Meeting and voting in person.
4


Please note, however, that if your shares are held of record by a brokerage firm, bank or other nominee, you must instruct your broker, bank or other nominee that you wish to change your vote by following the procedures on the voting form provided to you by the broker, bank or other nominee. If your shares are held in street name, and you wish to attend and vote at the Annual Meeting, you must bring to the Annual Meeting a legal proxy from the broker, bank or other nominee holding your shares, confirming your beneficial ownership of the shares and giving you the right to vote your shares. Simply attending the Annual Meeting will not constitute a revocation of your proxy.
Who will bear the costs of the proxy solicitation?

We will bear the costs of soliciting proxies. We have retained Morrow Sodali LLC to assist us in our proxy solicitation for an aggregate fee of approximately $8,000, plus out-of-pocket expenses. We expect to pay banks, brokers and other nominees their reasonable expenses for forwarding proxy materials and annual reports to principals and obtaining their voting instructions. In addition to solicitations by mail, our directors, officers and regular employees, without additional remuneration, may solicit proxies by telephone, facsimile, email, personal interviews and other means.


When will the voting results be announced?

We plan to announce preliminary voting results at the Annual Meeting and will publish final results in a Current Report on Form 8-K to be filed with the SEC within four business days following the Annual Meeting.
5



PROPOSAL NO. 1—1 – ELECTION OF TWOONE CLASS II DIRECTORSDIRECTOR
Our Board is divided into three classes, with one class of our directors standing for election each year for a three-year term. Directors for each class are elected at the annual meeting of stockholders held in the year in which the term for their class expires and hold office until their resignation or removal or their successors are duly elected and qualified. In accordance with our certificate of incorporation and bylaws,by-laws, our directors may fill existing vacancies on theour Board by appointment. The members of the classes are divided as follows:
the Class I Directors are Peter Barton Hutt, Wilfred E. Jaeger and Roger D. Tung, and their term will expire at theour 2024 annual meeting of stockholders to be held in 2021;
stockholders;
the Class II Directors are Ronald W. Barrett and Jesper Høiland, and Wendell Wierenga and their term will expire at the annual meeting of stockholders to be held in 2019;Annual Meeting; and
the Class III Directors are Richard H. Aldrich, Thomas G. Auchincloss, Jr. and Christine van Heek, and their term will expire at theour 2023 annual meeting of stockholders to be held in 2020.stockholders.

Our Board is currently authorized to have eight members. However, Dr. Barrett notified us that he will not stand for re-election at the Annual Meeting. As a result, our Board has approved a decrease in its size to seven members effective as of the Annual Meeting.
Our Board, on the recommendation of our nominating and corporate governance committee, has nominated Mr. Høiland for re-election as a Class II Director at the Annual Meeting. If Mr. Høiland is re-elected at the Annual Meeting, he will serve for a three-year term that will expire at our 2025 annual meeting of stockholders.
Our certificate of incorporation and bylawsby-laws provide that the authorized number of directors may be changed only by resolution of our Board. Our certificate of incorporation and bylawsby-laws also provide that our directors may be removed only for cause by the affirmative vote of the holders of at least 75% of the votes that all our stockholders would be entitled to cast in an annual election of directors, and that any vacancy on our Board, including a vacancy resulting from an enlargement of our Board, may be filled only by vote of a majority of our directors then in office.
Our Board, on the recommendation of our nominating and corporate governance committee, has nominated Ronald W. Barrett for re-election as a Class II Director at the Annual Meeting and has also nominated Jesper Høiland as a new Class II Director for election as a Class II Director at the Annual Meeting. Each director that is elected at the Annual Meeting will be elected to serve for a three year term that will expire at our annual meeting of stockholders in 2022.
If no contrary indication is made, properly executed proxies in the accompanying form are to be voted for Ronald W. Barrett and JesperMr. Høiland or, in the event that either of these candidateshe is not a candidate or is unable to serve as a director at the time of election (which is not currently expected), for any nominee who is designated by our Board to fill the vacancy.
We have no formal policy regarding board diversity. Our priority in selection of board members is identification of members who will further the interests of our stockholders through their established record of professional accomplishment, the ability to contribute positively to the collaborative culture among board members, knowledge of our business, understanding of the competitive landscape and adherence to high ethical standards. Certain individual skills and qualifications of our directors, which we believe contribute to the effectiveness of the Board as a whole, are described in the paragraphs below.
Information Regarding Directors
The information set forth below as to the directors and the nominees for directors has been furnished to us by the directors and the nominees for directors.
Recommendation of theour Board
OUR BOARD UNANIMOUSLY RECOMMENDS THAT THE STOCKHOLDERS VOTE FOR THE ELECTION OF EACH DIRECTOR NOMINEE.MR. HØILAND.


Nominees
6



Nominee for Election to theour Board
For a Three-Year Term Expiring at the
20222025 Annual Meeting of Stockholders (Class II)

NameAgePresent Position with Concert Pharmaceuticals, Inc.
Ronald W. Barrett63
Director
Jesper Høiland6158
N/ADirector
Ronald W. Barrett, Ph.D. Jesper Høilandhas served as a member of our Board since April 2019. Mr. Høiland has served as the Global Commercial Officer of Directors since December 2007. Dr. Barrett wasAscendis Pharma A/S, a founder of XenoPort, Inc., a public biopharmaceutical company, and served as its Chief Executive Officer from 2001 to 2015, its Chief Scientific Officer from 1999 to 2001 and as a member of its board of directors from 1999 to 2015. Prior to XenoPort, Dr. Barrett held various positions at Affymax Research Institute, a drug discovery company now owned by GlaxoSmithKline plc, and Abbott Laboratories, a healthcare company. During the last five years, Dr. Barrett also served as a member of the board of directors of XenoPort. Dr. Barrett received a B.S. from Bucknell University and a Ph.D. in Pharmacology from Rutgers University. We believe that Dr. Barrett’s industry and board experience, including his experience as the chief executive officer of a publicly traded biopharmaceutical company, make him a key contributor to our Board of Directors.
Jespersince May 2020. Mr. Høiland haspreviously served as the President and Chief Executive Officer and as a member of the board of directors of Radius Health, Inc. since, a biopharmaceutical company, from July 2017. Prior2017 to joining Radius,May 2020. From 1987 to December 2016, Mr. Høiland served in various roles at Novo Nordisk A/S, a global healthcare company, including as President/Executive Vice President of Novo Nordisk Inc. USA, Novo Nordisk’s U.S. affiliate, and as the US affiliateleader of Novo Nordisk A/S, a global healthcare company focused on diabetes and other serious chronic conditions. After joining Novo Nordisk in 1987, Mr. Høiland held multiple global roles of increasing responsibility, including leading itsNordisk’s International Operations, which spanned 150 countries. During the last five years, Mr. Høiland has 30 years of experience in the biopharmaceutical industry across numerous senior leadership roles, geographies and therapeutic areas. He possesses extensive knowledge about the areas of endocrinology, biopharmaceuticals and women's health, as well as unique insights about U.S. market access. Mr. Høiland is a member ofpreviously served on the board of directors of LEO Pharma A/S, a pharmaceutical company focused on dermatology.S. Mr. Høiland received his M. Sc.a M.Sc. in Management from Copenhagen Business School in Denmark. We believe that Mr. Høiland is qualified to serve as a member of our Board because hisiland’s extensive operational knowledge of, and executive level management experience in, the global biopharmaceutical industry.industry make him a key contributor to our Board.

7





Members of theour Board Continuing in Office
Term Expiring at the
20212023 Annual Meeting of Stockholders (Class I)III)

NameAgePresent Position with Concert
Richard H. Aldrich67Director
Thomas G. Auchincloss, Jr.60Director
Christine van Heek65Director
Richard H. Aldrich is a co-founder of Concert and has served as a member of our Board and as Chairman of the Board since May 2006. Mr. Aldrich is a co-founder of and has been a Partner at Longwood Fund, a life sciences venture capital firm, since December 2010. Prior to co-founding Longwood Fund, Mr. Aldrich co-founded RA Capital Management LLC, a life sciences investment fund, in 2001. Mr. Aldrich has co-founded and helped to build several biotechnology companies including Sirtris Pharmaceuticals, Inc. (acquired by GlaxoSmithKline in 2008), Alnara Pharmaceuticals, Inc. (acquired by Eli Lilly in 2010), Verastem, Inc., Axial Therapeutics, Inc. and TScan Therapeutics, Inc. Mr. Aldrich was also a founding employee of Vertex Pharmaceuticals Incorporated, a pharmaceutical company, where he held the position of Senior Vice President and Chief Business Officer and managed all commercial and operating functions from 1989 to 2001. Prior to joining Vertex, Mr. Aldrich held several management positions at Biogen Inc. Mr. Aldrich also serves on the board of directors of a number of private biotechnology companies. During the last five years, Mr. Aldrich previously served on the board of directors of KalVista Pharmaceuticals, Inc. and OvaScience, Inc. Mr. Aldrich received a B.S. in Management from Boston College and an M.B.A. from the Amos Tuck School at Dartmouth College. We believe that Mr. Aldrich’s broad-based experience in business, including his leadership and board experience at life science companies, and his familiarity with our business as a co-founder of Concert make him a key contributor to our Board.
Thomas G. Auchincloss, Jr. has served as a member of our Board since December 2014. Since September 2013, Mr. Auchincloss has served as Managing Member at Counterpoint Trading Company, LLC, a private investment firm. From August 2007 to September 2013, Mr. Auchincloss was self-employed in private investing. From May 2005 to August 2007, Mr. Auchincloss worked as Chief Financial Officer of Metabolix, Inc., a biomaterials company. Prior to that, Mr. Auchincloss served as a consultant with Metabolix from April 2002 to May 2005, providing business development, financial and strategic consulting services. From 1994 to 2001, Mr. Auchincloss served in a variety of positions at Vertex Pharmaceuticals Incorporated, a pharmaceutical company, most recently as Vice President, Finance and Treasurer. Mr. Auchincloss received a B.S. in Business Administration from Babson College and an M.B.A. in Finance from the Wharton School. We believe that Mr. Auchincloss’ financial and industry experience, including his experience as the chief financial officer of a publicly traded biomaterials company, make him a key contributor to our Board.
Christine van Heek has served as a member of our Board since April 2016. Ms. van Heek has served as an adviser and consultant to several companies in the biopharmaceutical industry. From 1991 to 2003, Ms. van Heek served in various roles at Genzyme Corporation, a biotechnology company, including as Corporate Officer and President, Therapeutics Division; General Manager, Renal Division; and Vice President, Global Marketing. In addition, she has held various sales and marketing positions at Genentech, Inc. and Caremark/HHCA. Ms. van Heek also serves on the board of directors of Visioneering Technologies, Inc. Ms. van Heek received a B.S.N. from the University of Iowa and an M.B.A. from Lindenwood University in St. Louis. We believe that Ms. van Heek’s industry experience, including her extensive experience in strategic roles at a publicly traded biotechnology company, make her a key contributor to our Board.

8



Term Expiring at the
2024 Annual Meeting of Stockholders (Class I)

NameAgePresent Position with Concert
Peter Barton Hutt84
87Director
Wilfred E. Jaeger, M.D.63
66Director
Roger D. Tung, Ph.D.59
62Director, Chief Executive Officer and President
Peter Barton Hutt has served as a member of our Board of Directors since December 2006. Mr. Hutt has practiced law at Covington & Burling LLP, specializing in food and drug law, since 1960 (except for the period from 1971 to 1975) and currently serves as senior counsel. From 1971 to 1975, he was Chief Counsel for the Food and Drug Administration. Mr. Hutt isalso serves on the board of directors of a membernumber of private companies. During the last five years, Mr. Hutt previously served on the board of directors of Flex Pharma, Inc., Immunomedics, Inc., Moderna, Inc., Immunomedics, Inc. and Q Therapeutics, Inc., each of which is a public biotechnology company, as well as numerous private companies. During the last five years, Mr. Hutt also served as a member of the board of directors of BINDRubius Therapeutics, Inc., Seres Health,Therapeutics, Inc., Xoma Ltd., DBV Technologies SA, a public biotechnology company, and Momenta Pharmaceuticals, Inc., a public biotechnology company.XOMA Corporation. Mr. Hutt received a B.A. from Yale University, an LL.B. from Harvard Law School and an LL.M. from New York University School of Law. We believe that Mr. Hutt’s extensive knowledge of regulatory and legal issues related to drug development and his service on numerous boards of directors allowmake him to be a key contributor to our Board of Directors.Board.
Wilfred E. Jaeger, M.D. has served as a member of our Board of Directors since May 2006. Dr. Jaeger co-founded Three Arch Partners, a venture capitalhealthcare-focused investment firm, in 1993 and has served as a Partner since that time.Managing Member until December 2019. Prior to co-founding Three Arch Partners, Dr. Jaeger was a general partner at Schroder Ventures. He isDr. Jaeger also a member ofserves on the board of directors of Threshold Pharmaceuticals,Neuronetics, Inc., a public pharmaceutical company, and Nevro Corporation, a public medical device company, as well as numerousa number of private companies. During the last five years, Dr. Jaeger previously served on the board of directors of Nevro Corp. and Threshold Pharmaceuticals, Inc. Dr. Jaeger received a B.S. in Biology from the University of British Columbia, hisan M.D. from the University of British Columbia School of Medicine and an M.B.A. from Stanford University. We believe that Dr. Jaeger’s financial and medical knowledge and experience allowmake him to be a key contributor to our Board of Directors.Board.

Roger D. Tung, Ph.D., Ph.D. is our co-founderscientific founder and has served as our President and Chief Executive Officer and as a member of our Board of Directors since April 2006. He is also a member of the board of directors of Flex Pharma, Inc., a public pharmaceutical company. Before founding Concert, Dr. Tung was a founding scientist at Vertex Pharmaceuticals Incorporated, a pharmaceutical company, where he was employed from 1989 to 2005, most recently as its Vice President of Drug Discovery. Prior to Vertex, he held various positions at Merck, Sharp & Dohme Research Laboratories, a global healthcare provider, and The Squibb Institute for Medicinal Chemistry. During the last five years, Dr. Tung previously served on the board of directors of Flex Pharma, Inc. Dr. Tung received a B.A. in Chemistry from Reed College and a Ph.D. in Medicinal Chemistry from the University of Wisconsin-Madison. We believe that Dr. Tung’s detailed knowledge of our CompanyConcert and his 34-yearlong career in the global pharmaceutical and biotechnology industries, including his roles at Vertex, provide a critical contribution to our Board of Directors.



Term Expiring at the
2020 Annual Meeting of Stockholders (Class III)
NameAgePresent Position with Concert Pharmaceuticals, Inc.
Richard H. Aldrich64
Director
Thomas G. Auchincloss, Jr.57
Director
Christine van Heek62
Director
Richard H. Aldrich is our co-founder and has served as a member of our Board of Directors and as Chairman of our Board of Directors since May 2006. Mr. Aldrich is a co-founder and has been a Partner of Longwood Fund, a venture capital firm, since December 2010. Mr. Aldrich has been an employee of Longwood Management LLC since August 2015. Mr. Aldrich founded RA Capital Management LLC, a hedge fund, in 2001 and served as a Managing Member from 2001 to 2008 and as a Co-Founding Member from 2008 until 2011. Mr. Aldrich has co-founded and helped to build several biotechnology companies including Sirtris Pharmaceuticals, Inc., (acquired by GlaxoSmithKline in 2008), Alnara Pharmaceuticals, Inc. (acquired by Eli Lilly in 2010), Verastem, Inc., OvaScience, Inc. and Flex Pharma, Inc. Mr. Aldrich was also a founding employee of Vertex Pharmaceuticals Incorporated, where he held the position of Senior Vice President and Chief Business Officer and managed all commercial and operating functions from 1989 to 2001. Prior to joining Vertex, Mr. Aldrich held several management positions at Biogen Inc. Mr. Aldrich also serves on the boards of a number of private biotechnology companies. During the last five years, Mr. Aldrich also served as a member of the board of directors of PTC Therapeutics, Inc. and Verastem, Inc., both of which are public biopharmaceutical companies, as well as OvaScience, Inc., a public biopharmaceutical company at the time of its merger with Millendo Therapeutics, Inc. in 2018. Mr. Aldrich received his B.S. in Management from Boston College and an M.B.A. from the Amos Tuck School at Dartmouth College. We believe Mr. Aldrich’s broad-based experience in business, including his leadership and board experience at life science companies, and his familiarity with our business as a co-founder of our company allow him to be a key contributor to our Board of Directors.
Thomas G. Auchincloss, Jr. has served as a member of our Board of Directors since December 2014. Since October 2013, Mr. Auchincloss has served as Managing Partner at Counterpoint Trading Company, LLC, a private investment firm. From August 2007 through September 2013, Mr. Auchincloss was self-employed in private investing. From May 2005 to August 2007, Mr. Auchincloss worked as Chief Financial Officer of Metabolix, Inc., a public biomaterials company. Prior to that, Mr. Auchincloss served as a consultant with Metabolix, from April 2002 to May 2005, providing business development, financial and strategic consulting services. From 1994 to 2001, Mr. Auchincloss served in a variety of positions at Vertex Pharmaceuticals Incorporated, most recently as Vice President, Finance and Treasurer. Mr. Auchincloss received a B.S. in Business Administration from Babson College and an M.B.A. in Finance from the Wharton School. We believe that Mr. Auchincloss’ financial and industry experience, including his experience as the chief financial officer of a publicly traded biomaterials company, make him a key contributor to our Board of Directors.Board.
9


Christine van Heek has served as a member of our Board of Directors since April 2016. Ms. van Heek has served as an adviser and consultant to several companies in the bio-pharmaceutical industry. From 1991 to 2003, Ms. van Heek served in various roles at Genzyme, Inc., a biotechnology company, including positions as Corporate Officer and President, Therapeutics Division; General Manager, Renal Division; and Vice President, Global Marketing. In addition, she has held various sales and marketing positions at Genentech, Inc. and Caremark/HHCA. During the last five years, Ms. van Heek also served as a member of the board of directors of Affymax, Inc., a biopharmaceutical company. Ms. van Heek holds an M.B.A. from Lindenwood University in St. Louis and a B.S.N. from the University of Iowa. We believe that Ms. van Heek's industry experience, including her extensive experience in strategic roles of a publicly traded biotechnology company, make her a key contributor to our Board of Directors.


CORPORATE GOVERNANCE
General
We believe that good corporate governance is important to ensure that the CompanyConcert is managed for the long-term benefit of our stockholders. This section describes key corporate governance practices that we have adopted. We have adopted a code of business conduct and ethics, which applies to all of our employees, officers directors and employees, anddirectors, corporate governance guidelines and charters for our audit committee, our compensation committee and our nominating and corporate governance committee. We have posted copies of our code of business conduct and ethics and corporate governance guidelines, as well as each of our committee charters, on the “Corporate Governance” page of the “Investors” section of our website, www.concertpharma.com, which you can access free of charge. Information contained on theour website is not incorporated by reference in, or considered part of, this proxy statement. We intend to disclose on our website any amendments to, or waivers from, our code of business conduct and ethics that are required to be disclosed by law or NASDAQ listing standards.the Nasdaq Listing Rules. We will also provide copies of these documents as well as our other corporate governance documents, free of charge, to any stockholder upon written request to Concert Pharmaceuticals, Inc., 65 Hayden Avenue, Suite 3000N, Lexington, MA 02421, Attention: Investor Relations.
Director Independence
Rule 5605 of the NASDAQ Listing Rules requires a majority of a listed company’s board of directors to be comprised of independent directors within one year of listing. In addition, the NASDAQThe Nasdaq Listing Rules require that, subject to specified exceptions, each member of a listed company’s audit, compensation and nominating and corporate governance committees be independent, that audit committee members satisfy heightened independence criteria set forthrequirements contained in Rule 10A-3 underof the Securities Exchange Act of 1934, (asas amended the “Exchange Act”(the “Exchange Act), and that compensation committee members also satisfy heightened independence requirements contained in the NASDAQNasdaq Listing Rules, as well as Rule 10C-1 underof the Exchange Act.
Under Rule 5605(a)(2), a director will only qualify as an “independent director” if, in the opinion of our Board, that person does not have a relationship that would interfere with the exercise of independent judgment in carrying out the responsibilities of a director.
In order to be considered independent for purposes of Rule 10A-3, a member of anthe audit committee of a listed company may not, other than in his or her capacity as a member of the audit committee, the Board,board of directors or any other board committee, accept, directly or indirectly, any consulting, advisory or other compensatory fee from the listed company or any of its subsidiaries or otherwise be an affiliated person of the listed company or any of its subsidiaries.
When determining the independence of the members of our compensation committee under the heightened independence requirements contained in the NASDAQNasdaq Listing Rules and Rule 10C-1, our Board is required to consider all factors specifically relevant to determining whether a director has a relationship with us that is material to that director’s ability to be independent from management in connection with the duties of a compensation committee member, including, but not limited to: (1) the source of compensation of that director, including any consulting, advisory or other compensatory fee paid by us to that director; and (2) whether that director is affiliated with the Company,Concert, a subsidiary of the CompanyConcert or an affiliate of a subsidiary of the Company.Concert.

Our Board has reviewed the composition of our Board and its committees and the independence of each director. Based upon information requested from and provided by each director concerning his or her background, employment and affiliations, including family relationships, our Board has determined that each of our directors, with the exception of Dr. Tung, is an “independent director” as defined under Rule 5605(a)(2) of the NASDAQNasdaq Listing Rules. Our Board also determined that Mr. Auchincloss, Dr. Jaeger and Ms. van Heek, who comprise our audit committee, and Dr. Barrett, Mr. HuttHøiland and Mr. Høiland,Dr. Jaeger, who comprise our compensation committee, satisfy the independence standards for such committees established by the SEC and the NASDAQNasdaq Listing Rules, as applicable. In making such determinations, our Board considered the relationships that each such non-employee director has with the CompanyConcert and all other facts and circumstances our Board deemed relevant in determining independence, including the beneficial ownership of our capital stock by each non-employee director.
10



Board Leadership Structure
Our Board is currently chaired by Mr. Aldrich, an independent director, who possesses an in-depth knowledge of our business, opportunities and challenges. We believe hethat separation of the positions of Board Chair and Chief Executive Officer reinforces the independence of the Board in its oversight of our business and affairs. We believe that Mr. Aldrich is the person best positioned to ensure that our Board’s time and attention is focused on the most critical matters. In addition, we believe that having an independent Board Chair creates an environment that is more conducive to objective evaluation and oversight of management’s performance, which increases management accountability and improves the ability of the Board to monitor whether management’s actions are in the best interests of the company and its stockholders. As a result, we believe that having an independent Board Chair can enhance the effectiveness of the Board as a whole.

Board Size

Our Board periodically considers its appropriate size, function, needs and composition. Currently, our Board has eight members; however, Dr. Barrett is not standing for re-election at the Annual Meeting. Therefore, following the Annual Meeting, the size of our Board will be reduced to seven members. Our Board may expand or reduce its size further in the future if it determines a change is appropriate. Our nominating and corporate governance committee also periodically reviews the size of our Board and recommends any proposed changes.
Board Diversity
We do not have a formal policy regarding board diversity. However, in considering director nominees, our nominating and corporate governance committee considers, among other factors, diversity of background and perspective, including with respect to age, gender, race, place of residence and specialized experience. Our priority in selecting Board members is the identification of members who will further the interests of our stockholders through their established record of professional accomplishment, the ability to contribute positively to the collaborative culture among Board members, knowledge of our business, understanding of the competitive landscape and adherence to high ethical standards.
The following table provides information related to the gender identity and demographic background of our Board members, as self-identified by our Board members.
Board Diversity Matrix (As of April 12, 2022)
Total Number of Directors8
FemaleMale
Part I: Gender Identity
Directors17
Part II: Demographic Background
Asian01
White16
Our Board’s Role in Risk Oversight
Our Board has responsibility for the oversight of the company’sConcert’s risk management processes and, either as a whole or through its committees, regularly discusses with management our major risk exposures, the potential impact of these risks on our business and the steps we take to manage them. The risk oversight process includes receiving regular reports from Board committees and members of senior management to enable our Board to understand the company’sConcert’s risk identification, risk management and risk mitigation strategies with respect to areas of potential material risk, including operations, finance, legal, regulatory, strategic and reputational risk.
The audit committee reviews information regarding liquidity and operations and oversees our management of financial risks. Periodically, the audit committee reviews our policies with respect to risk assessment, risk management, loss prevention and
11



regulatory compliance. Oversight by the audit committee includes direct communication with our external auditors and discussions with management regarding significant risk exposures and the actions management has taken to limit, monitor or control such exposures. The compensation committee is responsible for assessing whether any of our compensation policies or programs have the potential to encourage excessive risk-taking. The nominating and corporate governance committee manages risks associated with the independence of theour Board, corporate disclosure practices and potential conflicts of interest. While each committee is responsible for evaluating certain risks and overseeing the management of such risks, the entire Board is regularly informed through committee reports about such risks. Matters of significant strategic risk are considered by our Board as a whole.
Board Meetings
Our Board met six12 times during our fiscal year 2018,2021, including telephonic meetings.meetings, and took action by written consent twice. During the year, each of our directors attended 75% or more of the combined total number of meetings of theour Board and the committees on which he or she served.
Committees of theour Board
We have three standing committees: the audit committee, the compensation committee and the nominating and corporate governance committee. Each of these committees has a written charter approved by our Board. A copy of each charter can be found on the “Corporate Governance” page of the “Investors” section of our website, at www.concertpharma.com.
Audit Committee
The members of our audit committee are Mr. Auchincloss, Dr. Jaeger and Ms. van Heek. Mr. Auchincloss is the chair of the audit committee. Our Board has determined that each of Mr. Auchincloss and Dr. Jaeger qualifies as an audit committee financial expert within the meaning of SEC regulations and the NASDAQNasdaq Listing Rules.
In making this determination, our Board has considered the formal education and nature and scope of each such director’s previous experience, coupled with past and present service on various audit committees. Our audit committee assists our Board in its oversight of our accounting and financial reporting process and the audits of our financial statements. The audit committee met nine times during fiscal year 2018,2021, including telephonic meetings. The audit committee’s responsibilities include:
appointing, approving the compensation of, and assessing the independence of our independent registered public accounting firm;
overseeing the work of our independent registered public accounting firm, including through the receipt and consideration of reports from such firm;
reviewing and discussing with management and the independent registered public accounting firm our annual and quarterly financial statements and related disclosures;
monitoring our internal control over financial reporting, disclosure controls and procedures and code of business conduct and ethics;
overseeing our internal audit function, if any;
discussing our risk management policies;

establishing policies regarding hiring employees from the independent registered public accounting firm and procedures for the receipt, retention and treatment of accounting related complaints and concerns;
meeting independently with our internal auditing staff, independent registered public accounting firm and management;
reviewing and approving or ratifying any related person transactions; and
preparing the audit committee report required by SEC rules.
We believe that the composition of our audit committee meets the requirements for independence under current NASDAQ listing standardsthe Nasdaq Listing Rules and SEC rules and regulations. Our Board has determined that each of Mr. Auchincloss, Dr. Jaeger and Ms. van Heek is independent as independence is currently defined in applicable NASDAQ listing standards.the Nasdaq Listing Rules and Rule 10A-3 of the Exchange Act.
12



Compensation Committee
The members of our compensation committee are Dr. Barrett, Mr. HuttHøiland and Mr. Høiland.Dr. Jaeger. Dr. Barrett is the chair of the compensation committee. Our compensation committee assists our Board in the discharge of its responsibilities relating to the compensation of our executive officers. The compensation committee met six times during fiscal year 2018.2021, including telephonic meetings. The compensation committee’s responsibilities include:
reviewing and making recommendations to our Board with respect to the compensation of our chief executive officer, and reviewing and approving, or making recommendations to our Board with respect to, the compensation of our chief executive officer and our other executive officers;
overseeing and administering our cash and equity incentive plans;
reviewing and making recommendations to our Board with respect to director compensation;
appointing, compensating and overseeing the work of any compensation consultant, legal counsel or other adviser retained by the compensation committee;
conducting an independence assessment with respect to any compensation consultant, legal counsel or other adviser retained by the compensation committee;
reviewing and discussing with management our director and executive compensation disclosure required to be included in our annual reportAnnual Report on Form 10-K or proxy statement; and
preparing the compensation committee report required by SEC rules, if applicable.
The compensation committee may delegate to one or more executive officers the power to grant options or other stock awards pursuant to our equity incentive plans to employees who are not directors or executive officers, subject to certain limitations. The compensation committee may also form and delegate its responsibilities to one or more subcommittees of theour Board.

We believe that the composition of our compensation committee meets the requirements for independence under current NASDAQ listing standardsthe Nasdaq Listing Rules and SEC rules and regulations. Our Board has determined that each of Dr. Barrett, Mr. HuttHøiland and Mr. HøilandDr. Jaeger is independent as independence is currently defined in applicable NASDAQ listing standards.the Nasdaq Listing Rules and Rule 10C-1 of the Exchange Act.
Nominating and Corporate Governance Committee
The members of our nominating and corporate governance committee are Mr. Aldrich and Mr. Hutt. Mr. Aldrich is the chair of the nominating and corporate governance committee. The nominating and corporate governance committee met one timetwo times during fiscal year 2018.2021, including telephonic meetings. The nominating and corporate governance committee’s responsibilities include:
identifying individuals qualified to become boardBoard members;
recommending to our Board the persons to be nominated for election as directors and to each committee of our Board;

reviewing and making recommendations to our Board with respect to management successsuccession planning;
developing and recommending corporate governance principles to theour Board; and
overseeing periodic evaluations of theour Board.
We believe that the composition of our nominating and corporate governance committee meets the requirements for independence under current NASDAQ listing standardsthe Nasdaq Listing Rules and SEC rules and regulations. Our Board has determined that each of Mr. Aldrich and Mr. Hutt is independent as independence is currently defined in applicable NASDAQ listing standards.the Nasdaq Listing Rules.
Code of Business Conduct and Ethics
We haveOur Board has adopted a written code of business conduct and ethics that applies to our directors,employees, officers and employees,directors, including our principal executive officer, principal financial officer, principal accounting officer or controller, or persons performing similar functions. InOn the “Corporate Governance” page of the “Investors” section onof our website, www.concertpharma.com, we have posted a current copy of the code of business conduct and ethics and all disclosures that
13



are required by law or NASDAQ listing standardsthe Nasdaq Listing Rules concerning any amendments to, or waivers from, any provision of this code. Information contained on our website is not incorporated by reference in, or considered part of, this proxy statement.
Policy on Trading, Pledging and Hedging of Company Stock
Certain transactions in our securities (such as short sales and purchases and sales of put and call options) create a heightened compliance risk or could create the appearance of misalignment between management and stockholders. In addition, securities held in a margin account or pledged as collateral may be sold without consent if the owner fails to meet a margin call or defaults on the loan, thus creating the risk that a sale may occur at a time when an officer or director is aware of material, non-public information or otherwise is not permitted to trade in our securities. Our insider trading policy expressly prohibits short sales of our securities and purchases and sales of puts, calls and other derivative securities based on our securities by our employees, officers and directors. Our insider trading policy also expressly prohibits our employees, officers and directors from purchasing our securities on margin, borrowing against our securities held in a margin account and pledging our securities as collateral for a loan; however, an exception may be granted where a person wishes to pledge our securities as collateral for a loan and clearly demonstrates the financial capacity to repay the loan without resorting to the pledged securities.
Related Person Transactions
Our Board has adopted written policies and procedures for the review of any transaction, arrangement or relationship in which Concert is a participant, the amount involved exceeds $120,000 and one of our executive officers, directors, director nominees or 5% stockholders, or their immediate family members, each of whom we refer to as a “related person,” has a direct or indirect material interest.
In November 2021, we closed a financing (the “2021 Financing”) pursuant to which we received aggregate gross proceeds of $65.0 million. The 2021 Financing consisted of the sale of (i) 13,997 shares of Series X1 preferred stock, (ii) 2,253,000 shares of common stock, (iii) warrants to purchase up to 16,250 shares of Series X1 preferred stock and (iv) a portion of our right to receive potential future AVP-786 royalties under a development and license agreement with Avanir Pharmaceuticals, Inc. (the “Avanir Agreement”). One of the investors in the 2021 Financing was RA Capital Healthcare Fund, L.P. (“RA Capital”). At the time of entering into the 2021 Financing, RA Capital held greater than 5% of our outstanding common stock, and two members of our board of directors, Mr. Aldrich and Dr. Tung, maintained minority, non-controlling interests in RA Capital. RA Capital purchased 7,500 shares of Series X1 preferred stock, warrants to purchase up to 7,500 shares of Series X1 preferred stock and 16.2%, which could potentially increase up to 23.1%, of our right to receive potential future AVP-786 royalties under the Avanir Agreement for $30.0 million in cash. Mr. Aldrich and Dr. Tung recused themselves from the negotiation of the 2021 Financing, and our Board (with Mr. Aldrich and Dr. Tung abstaining) and audit committee approved the 2021 Financing in accordance with our related person transaction policy.
Other than the 2021 Financing, we have not engaged in any related person transactions since January 1, 2021.
Director Nomination Process
Our nominating and corporate governance committee is responsible for identifying individuals qualified to serve as directors, consistent with criteria approved by our Board, and recommending the persons to be nominated for election as directors.
Director Qualifications
In evaluating director nominees, theour nominating and corporate governance committee will consider, among other things, the following factors:
14



reputation for personal and professional integrity, honesty and adherence to high ethical standards;
demonstrated business acumen, experience and ability to exercise sound judgments in matters that relate to the current and long-term objectives of the Company;
Concert;
strong finance experience;
commitment to understanding the CompanyConcert and its industry;
interest and ability to understand the sometimes conflicting interests of the various constituencies of the Company,Concert, which include stockholders, employees, customers, governmental units, creditors and the general public, and to act in the interests of all stockholders;
diversity of expertise and experience in substantive matters pertaining to our business relative to our other Board members;
diversity of background and perspective, including with respect to age, gender, race, place of residence and specialized experience; and
practical and mature business judgment, including the ability to make independent analytical inquiries.
The nominating and corporate governance committee’s goal is to assemble a Board that brings to the CompanyConcert a variety of perspectives and skills derived from high quality business and professional experience. Moreover, the nominating and corporate governance committee believes that the background and qualifications of theour Board, considered as a group, should provide a significant mix of experience, knowledge and abilities that will allow theour Board to fulfill its responsibilities. Nominees are not discriminated against on the basis of race, religion, national origin, sex, sexual orientation, disability or any other basis proscribed by law.
The nominating and corporate governance committee has not adopted a formal policy with respect to a fixed set of specific

minimum qualifications for its candidates for membership on theour Board. The nominating and corporate governance committee may consider such other facts, including, without limitation, diversity, as it may deem are in the best interests of the CompanyConcert and its stockholders. The nominating and corporate governance committee further believes it is appropriate for at least one member of our Board to meet the criteria for an “audit committee financial expert” as that phrase is defined under the regulations promulgated by the SEC, and that a majority of the members of our Board be independent as required under the NASDAQ qualification standards.Nasdaq Listing Rules. The nominating and corporate governance committee believes it is appropriate for our chief executive officer to serve as a member of our Board. Our directors’ performance and qualification criteria are reviewed periodically by the nominating and corporate governance committee.
Identification and Evaluation of Nominees for Directors
The nominating and corporate governance committee identifies nominees for director by first evaluating the current members of our Board willing to continue in service. Current members with qualifications and skills that are consistent with the nominating and corporate governance committee’s criteria for Board service and who are willing to continue in service are considered for re-nomination, balancing the value of continuity of service by existing members of our Board with that of obtaining a new perspective or expertise.
If any member of our Board does not wish to continue in service or if our Board decides not to re-nominate a member for re-election and desires to fill the vacancy on the Board, the nominating and corporate governance committee identifieswill work to identify a new nominee that meets the criteria above. The nominating and corporate governance committee generally inquires of our Board and members of management for their recommendations. The nominating and corporate governance committee may also review the composition and qualification of the boards of directors of our competitors, and may seek input from industry experts or analysts. The nominating and corporate governance committee reviews the qualifications, experience and background of suggested candidates. Final candidates, if other than our current directors, would be interviewed by the members of the nominating and corporate governance committee and by certain of our other independent directors and executive management. In making its determinations, the nominating and corporate governance committee evaluates each individual in the context of our Board as a whole, with the objective of assembling a group that can best contribute to the success of the CompanyConcert and represent stockholder interests through the exercise of sound judgment. After review and deliberation of all feedback and data, the nominating and corporate governance committee makes its recommendation to our Board.

We have not received director candidate recommendations from our stockholders and do not have a formal policy regarding consideration of such recommendations. However, any recommendations received from stockholders will be evaluated in the
15



same manner that potential nominees suggested by Board members, management or other parties are evaluated. We do not intend to treat stockholder recommendations in any manner differently from other recommendations.
Under our bylaws,by-laws, stockholders wishing to nominate a candidate for director should write to our corporate secretary. In order to give the nominating and corporate governance committee sufficient time to evaluate a recommended candidate and/or include the candidate in our proxy statement for the 2020 Annual Meeting,2023 annual meeting of stockholders, the recommendation should be received by our corporate secretary at our principal executive offices in accordance with our procedures detailed in the section below entitled “Other Matters – Stockholder Proposals.. Such submissions must state the nominee’s name, together with appropriate biographical information and background materials, and information with respect to the stockholder or group of stockholders making the recommendation, including the number of shares of common stock owned by such stockholder or group of stockholders, as well as other information required by our bylaws.by-laws. We may require any proposed nominee to furnish such other information as we may reasonably require to determine the eligibility of such proposed nominee to serve as an independent director or that could be material to a reasonable stockholder’s understanding of the independence, or lack thereof, of such proposed nominee.
Director Attendance at Annual Meetings
Although the CompanyConcert does not have a formal policy regarding attendance by members of our Board at ourthe Annual Meeting, we encourage all of our directors to attend. EightSeven of our eight directors attended our 20182021 annual meeting of stockholders.
Communications with Our Board
Stockholders seeking to communicate with our Board should submit their written comments to Concert Pharmaceuticals, Inc., 65 Hayden Avenue, Suite 3000N, Lexington, MA 02421, Attention: Corporate Secretary. The corporate secretary will forward such communications to each member of our Board;Board, provided that, if in the opinion of our corporate secretary it would be inappropriate to send a particular stockholder communication to a specific director, such communication will only be sent to the remaining directors (subject to the remaining directors concurring with such opinion).

Director Compensation
During 2018,2021, we did not provide any compensation to Dr. Tung, our President and Chief Executive Officer, for his service as a member of our Board. Dr. Tung’s compensation as an executive officer is set forth below under “Executive Compensation-2017Compensation – 2021 Summary Compensation Table.”
Non-employee director compensation is set by our Board of Directors at the recommendation of our compensation committee. In April 2018, the compensation committee retained Radford, an AON Hewitt company, to assist in assessing our non-employee director compensation program and provide recommendations for changes to the program, if any. The 2018 peer group companies disclosed below under the heading “Executive Compensation - Narrative to the Summary Compensation Table” was used in the analysis, as well as other market data.
Under our director compensation program, we pay our non-employee directors a cash retainer for their service on theour Board of Directors and for their service on each committee of which the director is a member. The Chairman of the Board of Directors and the chairschair of each committee receive higher retainers for such service. These fees are payable quarterly in arrears, in four equal quarterly installments on the last day of each quarter, provided that the amount of such payment is prorated for any portion of such quarter that the director is not serving on our Board of Directors. Theor a committee.
For 2021, and continuing for 2022, the fees paid to non-employee directors for their service on theour Board of Directors and for their service on each committee of theour Board of Directors of which the director is a member are as follows:
Member Annual Retainer ($)Chair Annual Retainer ($)
Board of Directors40,00070,000
Audit Committee10,00020,000
Compensation Committee7,50015,000
Nominating and Corporate Governance Committee5,00010,000
     
  Annual Member Fee ($) Chairman Annual Fee ($)
Board of Directors 40,000
 70,000
Audit Committee 7,500
 15,000
Compensation Committee 6,250
 12,500
Nominating and Corporate Governance Committee 4,000
 8,000
For compensation payable after January 1, 2018, non-employeeNon-employee directors were given the optionmay elect to receive all or a portion of their cash retainer for their servicesthe one-year period following each annual meeting of stockholders in the form of a stock option award. The option will be granted on the date of the first Board meeting held after the annual meeting of stockholders that marks the beginning of the one-year period. The number of shares subject to any such options isthe option will be calculated using the fair market value of a share of our common stock on the date of grant. EachThese options will vest in equal quarterly installments over a one-year period measured from the date of thesethe annual meeting of stockholders that marks the beginning of the one-year period, subject to the director’s continued service as a director, and will vest in full
16



on the date that is one business day prior to the date of our next annual meeting of stockholders (if earlier than the one-year anniversary of the annual meeting of stockholders that marks the beginning of the one-year period).

In addition, on the date of the first Board meeting held after each annual meeting of stockholders, each non-employee director that has served on our Board for at least six months will receive an equity award, comprised of an option to purchase shares of our common stock and restricted stock units, that targets the 50th percentile of equity awards made by our peer group companies to their respective directors on an annual basis based on value and percent of company, as determined by Radford, our independent compensation consultant. Half of the award will consist of an option, the number of shares underlying which will be based on the average fair value of our common stock over the 30-day period ending on the March 31 preceding the date of grant. The other half of the award will consist of a number of restricted stock units equal to half of the number of shares underlying the option. These options vestswill vest in equal quarterly installments over a one-year period measured from the date of grant, but vests in full on the earlier of the date of the Company's annual meeting of stockholders held in the year following the grant date or the one-year anniversary of the grant date, subject to the director’s continued service as a director.
We These restricted stock units will vest on the one-year anniversary of the date of grant, subject to the director’s continued service as a director. These options and restricted stock units will also reimbursevest in full on the earlier of (i) the date that is one business day prior to the date of our non-employee directors for reasonable travelnext annual meeting of stockholders (if earlier than the one-year anniversary of the date of grant) and out-of-pocket expenses incurred(ii) a change in connection with attending our Boardcontrol of Directors and committee meetings.
Concert.
In addition, under our director compensation program, each new non-employee director elected to our Board will receive an equity award, comprised of Directors receives an option to purchase 25,000 shares of our common stock. Eachstock and restricted stock units, that targets two times the 50th percentile of theseequity awards made by our peer group companies to their respective directors on an annual basis based on value and percent of company, as determined by Radford. Half of the award will consist of an option, the number of shares underlying which will be based on the average fair value of our common stock over the 30-day period ending on the day before the director was elected to our Board. The other half of the award will consist of a number of restricted stock units equal to half of the number of shares underlying the option. These options will vest in equal quarterly installments over a three-year period measured from the date of grant, subject to the director’s continued service as a director, anddirector. These restricted stock units will become vested and exercisable in full upon a change in control of our Company. Further, on the date of the first board meeting held after each annual meeting of stockholders, each non-employee director that has served on our Board of Directors for at least six months receives an option to purchase 10,000 shares of our common stock. Each of these options vest in equal quarterlyannual installments over a one-yearthree-year period measured from the date of grant, subject to the director’s continued service as a director,director. These options and restricted stock units will become vested and exercisablealso vest in full upon a change in control of our Company. Concert.
The exercise price of each option isall options granted to non-employee directors will equal to the fairclosing market value of a shareprice of our common stock on the date of grant.
This program is intended to provide a total compensation package that enables us to attractWe also reimburse our non-employee directors for reasonable travel and retain qualifiedout-of-pocket expenses incurred in connection with attending Board and experienced individuals to serve as our directors and to align our directors’ interests with those of our stockholders.
In accordance with our director compensation program, in June 2018 we granted options to purchase 10,000 shares of our common stock to each non-employee director serving on the Board of Directors.



committee meetings.
The following table sets forth information regarding compensation earned by or awarded to our non-employee directors during 2018.2021.
NameFees earned or paid in cash ($)
Option
 awards ($) (1)
Stock
awards ($) (2)

Total ($)
Richard H. Aldrich80,000(3) 27,221 21,833 129,054
Thomas G. Auchincloss, Jr.60,000 27,221 21,833 109,054
Ronald W. Barrett55,000 27,221 21,833 104,054
Jesper Høiland47,500 27,221 21,833 96,554
Peter Barton Hutt45,000 27,221 21,833 94,054
Wilfred E. Jaeger57,500 27,221 21,833 106,554
Christine van Heek50,000(4) 27,221 21,833 99,054
17

Name Fees earned or
paid in cash or options ($) (1)
 Option awards ($)(2) Total ($)
Richard H. Aldrich 71,865
 133,748
 205,613
Thomas G. Auchincloss, Jr. 55,000
 133,748
 188,748
Ronald W. Barrett, Ph.D. 51,367
 133,748
 185,115
Meghan FitzGerald, Ph.D. 30,313
 133,748
 164,061
Christine van Heek 47,500
 133,748
 181,248
Peter Barton Hutt 47,573
 133,748
 181,321
Wilfred E. Jaeger, M.D. 47,500
 133,748
 181,248
Wendell Wierenga, Ph.D. 43,547
 133,748
 177,295


(1)In lieu of a cash retainer, Mr. Aldrich and Dr. FitzGerald received non-statutory stock options to purchase 5,940 and 3,453 shares, respectively, at an exercise price equal to the fair market value of a share of our common stock on the date of grant, June 14, 2018. Each of these options vest in equal quarterly installments over a one-year period measured from the date of grant but vesting in full on the earlier of the date of the Company's annual meeting of stockholders held in the year following the grant date or the one-year anniversary of the grant date, subject to the director’s continued service as a director. Dr. FitzGerald resigned as a member of the Board of Directors of the Company, effective December 11, 2018.
(2)The amounts included in the “Option awards” column reflect the aggregate grant date fair value of optionsoption awards granted during 20182021, calculated in accordance with Financial Accounting Standards Board (“FASB”) Accounting Standards Codification (“ASC”) Topic 718. Such aggregate grant date fair values do not take into account any estimated forfeitures related to service-vesting conditions. The amounts reported in this column reflect the accounting cost for these option awards and do not correspond to the actual economic value that may be received by the director upon exercise of the options. Assumptions used in the calculation of these amounts are included in Note 8 to the consolidated financial statements included in our 2021 Annual Report on Form 10-K. As of December 31, 2021, the aggregate number of shares of our common stock subject to each non-employee director’s outstanding option awards was as follows: Mr. Aldrich, 119,632; Mr. Auchincloss, 95,250; Dr. Barrett, 70,250; Mr. Høiland, 45,250; Mr. Hutt, 73,789; Dr. Jaeger, 70,250; and Ms. van Heek, 79,394.
(2)The amounts included in the “Stock awards” column reflect the aggregate grant date fair value of restricted stock units granted during 2021, calculated in accordance with FASB ASC Topic 718. Such aggregate grant date fair values do not take into account any estimated forfeitures related to service-vesting conditions. The amounts reported in this column reflect the accounting cost for these stock options,awards and do not correspond to the actual economic value that may be received by the director upon exercisevesting of the options.stock awards. Assumptions used in the calculation of these amounts are included in Note 8 to the consolidated financial statements appearingincluded in our 20182021 Annual Report on Form 10-K previously filed with the SEC.10-K. As of December 31, 2018,2021, the non-employee membersaggregate number of shares of our Board of Directors held the followingcommon stock subject to each non-employee director’s outstanding equity awards:
restricted stock unit awards was as follows: Mr. Aldrich, 5,125; Mr. Auchincloss, 5,125; Dr. Barrett, 5,125; Mr. Høiland, 5,125; Mr. Hutt, 5,125; Dr. Jaeger, 5,125; and Ms. van Heek, 5,125.
(3)Mr. Aldrich heldelected to receive all of his cash retainer for the periods from our 2020 annual meeting of stockholders to our 2021 annual meeting of stockholders and from our 2021 annual meeting of stockholders to the Annual Meeting in the form of stock option awards. As such, Mr. Aldrich was granted options to purchase 45,94013,260 shares of our common stock on June 11, 2020 and 30,182 shares of our common stock on June 10, 2021 based on the fair value of our common stock on such dates. The amount included in the aggregate,“Fees earned or paid in cash” column for Mr. Aldrich includes the fees that he would have otherwise received in cash in 2021 had he not elected to receive such fees in the form of which 37,970 sharesoptions that were vested, with the remaining shares scheduled to vest throughgranted on June 11, 2020 and including June 14, 2019;
10, 2021.
Mr. Auchincloss held stock options to purchase 65,000 shares of common stock in the aggregate, of which 60,000 shares were vested, with the remaining shares scheduled to vest through and including June 14, 2019;
Dr. Barrett held stock options to purchase 40,000 shares of common stock in the aggregate, of which 35,000 shares were vested, with the remaining shares scheduled to vest through and including June 14, 2019;
Dr. FitzGerald held stock options to purchase 34,196 shares of common stock in the aggregate, all of which were vested;
(4)Ms. van Heek heldelected to receive 50% of her cash retainer for the period from our 2020 annual meeting of stockholders to our 2021 annual meeting of stockholders in the form of a stock optionsoption award. As such, Ms. van Heek was granted an option to purchase 45,0004,144 shares of our common stock on June 11, 2020 based on the fair value of our common stock on such date. The amount included in the aggregate,“Fees earned or paid in cash” column for Ms. van Heek includes the fees that she would have otherwise received in cash in 2021 had she not elected to receive such fees in the form of which 35,833 shares were vested, with the remaining shares scheduled to vest through and includingan option that was granted on June 14, 2019;11, 2020.
18



Mr. Hutt held stock options to purchase 54,156 shares of common stock in the aggregate, of which 49,156 shares were vested, with the remaining shares scheduled to vest through and including June 14, 2019;
Dr. Jaeger held a stock option to purchase 40,000 shares of common stock, of which 35,000 shares were vested, with the remaining shares scheduled to vest through and including June 14, 2019; and
Dr. Wierenga held a stock option to purchase 68,538 shares of common stock, of which 63,538 shares were vested, with the remaining shares scheduled to vest through and including June 14, 2019.

CompensationAudit Committee Interlocks and Insider Participation
During 2018, the members of our compensation committee were Dr. Barrett, Mr. Hutt and Dr. FitzGerald. None of our executive officers serves, or in the past has served, as a member of the Board or compensation committee, or other committee serving an equivalent function, of any entity that has one or more executive officers who serve as members of our Board or our compensation committee. None of the members of our compensation committee is an officer or employee of the Company,

nor have they ever been an officer or employee of the Company.
Compensation Committee Report
The compensation committee reviewed and discussed the disclosure included in the section of this proxy statement entitled “Executive Compensation” with management. Based on the review and discussions, the compensation committee recommended to the Board that the section of this proxy statement entitled “Executive Compensation” be included in this proxy statement.
THE COMPENSATION COMMITTEE OF THE BOARD OF CONCERT PHARMACEUTICALS, INC.
Ronald R. Barrett, Ph.D., Chairman
Peter B. Hutt



REPORT OF THE AUDIT COMMITTEE OF THE BOARD OF CONCERT PHARMACEUTICALS, INC.
The audit committee is appointed by theour Board to assist theour Board in fulfilling its oversight responsibilities with respect to (1) the integrity of our financial statements and financial reporting process and systems of internal controls regarding finance, accounting, and compliance with legal and regulatory requirements, (2) the qualifications, independence and performance of our independent registered public accounting firm, (3) the performance of our internal audit function, if any, and (4) other matters as set forth in the charter of the audit committee approved by theour Board.
Management is responsible for the preparation of the Company’sConcert’s financial statements and the financial reporting process, including its system of internal control over financial reporting and its disclosure controls and procedures. The independent registered public accounting firm is responsible for performing an audit of the Company’sConcert’s financial statements in accordance with the standards of the Public Company Accounting Oversight Board or (“PCAOB”) and issuing a report thereon. The audit committee’s responsibility is to monitor and oversee these processes.
In connection with these responsibilities, the audit committee reviewed and discussed with management and the independent registered public accounting firm the audited consolidated financial statements of the CompanyConcert for the fiscal year ended December 31, 2018.2021. The audit committee also discussed with the independent registered public accounting firm the matters required to be discussed by the PCAOB’s Auditing Standard 1301, Communication with Audit Committees.applicable requirements of the PCAOB and SEC. In addition, the audit committee received written communications from the independent registered public accounting firm confirming its independence as required by the applicable requirements of the PCAOB and has discussed with the independent registered public accounting firm its independence.
Based on the reviews and discussions referred to above, the audit committee recommended to theour Board that the audited consolidated financial statements of the CompanyConcert be included in its Annual Report on Form 10-K for the fiscal year ended December 31, 20182021 that was filed with the SEC.
THE AUDIT COMMITTEE OF THE BOARD OF
DIRECTORS OF CONCERT
PHARMACEUTICALS, INC.By the audit committee of the board of directors of Concert Pharmaceuticals, Inc.
Thomas G. Auchincloss, ChairmanChair
Wilfred E. Jaeger
Christine van Heek


19



EXECUTIVE OFFICERS
The following table sets forth the name, age and positions of each of our executive officers as of February 22, 2019.
March 31, 2022.
NameAgePosition(s)
Executive Officers
Roger D. Tung, Ph. D.Ph.D.5962President, and Chief Executive Officer and Director
Marc A. Becker4750Chief Financial Officer
James V. Cassella, Ph.D.6467Chief Development Officer
Jeffrey A. Munsie44Chief Legal Officer and Secretary
Nancy Stuart6064Chief Operating Officer
Executive Officers

The biography of Dr. Tung can be found under “ProposalProposal No. 1:1 – Election of One Class I Directors - Nominees for Election to theII Director – Members of our Board -Continuing in Office – Term Expiring at the 20212024 Annual Meeting of Stockholders (Class I).”

Marc A.Becker has served as our Chief Financial Officer and principal financial officer since January 2018. Prior to joining Concert, Mr. Becker served as the Chief Financial Officer of CRISPR Therapeutics AG, a publicly traded biotechnology company, from February 2016 to September 2017. From January 2012 to February 2016, Mr. Becker wasserved as the Chief Financial Officer of rEVO Biologics, Inc., a biotechnology company. Prior to rEVO Biologics, Mr. Becker held roles of increasing responsibility at Genzyme Corporation, a biotechnology company subsequently acquired by Sanofi S.A., from August 2001 to October 2011, culminating in Vice President, Finance. Mr. Becker received an M.B.A. from Babson College and a B.S. in Business Administration from the University of Massachusetts and an M.B.A. from Babson College and was licensed as a certified public accountant.

James V. Cassella, Ph.D. has served as our Chief Development Officer since February 2015. Prior to joining Concert, Dr. Cassella served as Executive Vice President, Research and Development and Chief Scientific Officer of Alexza Pharmaceuticals, Inc., a biotechnology company, from July 2012 to January 2015 and served as its Senior Vice President, Research and Development from June 2004 to July 2012. From April 1989 to April 2004, Dr. Cassella held various management positions at Neurogen Corporation, a publicly traded biotechnology company. Prior to Neurogen, Dr. Cassella was Assistant Professor of Neuroscience at Oberlin College. Dr. Cassella also serves on the board of directors of Trevi Therapeutics, Inc. Dr. Cassella received a B.A. in Psychology from the University of New Haven and a Ph.D. in Physiological Psychology from Dartmouth College and completed a postdoctoral fellowship in the Department of Psychiatry at the Yale University School of MedicineMedicine.

Jeffrey A. Munsie has served as our Chief Legal Officer and Secretary since September 2019. Prior to joining Concert, Mr. Munsie served as General Counsel, Head of Corporate Operations and Secretary at Merrimack Pharmaceuticals, Inc., a biopharmaceutical company, until July 2019. Mr. Munsie joined Merrimack in February 2011 and became Secretary in August 2011, General Counsel in January 2013 and Head of Corporate Operations in March 2017. Previously, Mr. Munsie was Counsel in the corporate department at Wilmer Cutler Pickering Hale and Dorr LLP, a law firm, where he practiced from 2002 to January 2011. Mr. Munsie received an A.B. from Dartmouth College and a B.A. in PsychologyJ.D. from the University of New Haven.Harvard Law School.

Nancy Stuart has served as our Chief Operating Officer since October 2007 and was our Senior Vice President, Corporate Strategy and Operations from July 2006 to October 2007. Prior to joining Concert, Ms. Stuart held various business operations and business development positions at Amgen Inc., a biopharmaceutical company, Kinetix Pharmaceuticals, Inc., a pharmaceutical company subsequently acquired by Amgen, Scion Pharmaceuticals, Inc., a pharmaceutical company, Vertex Pharmaceuticals Incorporated, a pharmaceutical company, and Genzyme Corporation.Corporation, a biotechnology company. Ms. Stuart holdsalso serves on the board of directors of KalVista Pharmaceuticals, Inc. Ms. Stuart received a B.S. from the University of Michigan and an M.B.A. from the Simmons College Graduate School of Management.
20



EXECUTIVE COMPENSATION
20182021 Summary Compensation Table
The following table sets forth information regarding total compensation awarded to, earned by and paid to each individual who served as our chief executive officer during the year ended December 31, 20182021 and our two most highly-compensated executive officers (other than our chief executive officer) who were serving as executive officers as of December 31, 20182021 for services rendered in all capacities to the CompanyConcert for the years indicated below. We refer to these individuals as our “named executive officers”.officers.”
Name and principal positionYear
Salary
($)
Bonus
($)
Option awards
($) (1)
Stock awards
($) (2)
Non-equity incentive plan compensation
($) (3)
All other compensation
($) (4)
Total
($)
Roger D. Tung2021 599,426 1,641,743 905,751367,598 12,264 3,526,782
President and Chief Executive Officer2020581,9671,011,6571,098,957320,08212,1143,024,777
Marc A. Becker (5)
2021428,595415,241283,619238,9429,5101,375,907
Chief Financial Officer
James V. Cassella2021 464,152 483,713 283,619258,765 15,558 1,505,807
Chief Development Officer2020450,633283,144306,708225,31715,4081,281,210
Name Year Salary
($)
 Bonus
($)
 
Option awards
($)
(3)
 Stock awards ($) 
Non-equity
incentive plan
compensation
($)
(5)
 
All other
compensation
($)
(6)
 Total ($)
Roger D. Tung, Ph.D. 2018 535,511
 
 3,761,860
 
 300,421
 10,056
 4,607,848
President and Chief Executive Officer 2017 517,402
 
 1,496,440
 
1,109,600 (4)

 297,506
 9,906
 3,430,854
Nancy Stuart 2018 412,186
 
 1,316,651
 
 168,172
 11,022
 1,908,031
Chief Operating Officer 2017 398,247
 
 523,754
 
832,200 (4)

 183,194
 9,906
 1,947,301
Marc Becker (1)
     Chief Financial Officer
 2018 375,682
 
30,000 (2)

 1,880,930
 
 155,040
 8,880
 2,450,532

(1)Mr. Becker joined the Company as our Chief Financial Officer effective January 4, 2018 and was not a named executive officer for the fiscal year ended December 31, 2017, but is a named executive officer for the fiscal year ended December 31, 2018.
(2)Consists of a cash signing bonus earned upon the effective date of Mr. Becker's hire, January 4, 2018.
(3)
The amounts included in the “Option awards” column reflect the aggregate grant date fair value of option awards granted induring the years indicated, calculated in accordance with FASB ASC Topic 718. Such aggregate grant date fair values do not take into account any estimated forfeitures related to service-vesting conditions. The amounts reported in this column reflect the accounting cost for these stock options awards and do not correspond to the actual economic value that may be received by the named executive officer upon exercise of the options. Assumptions used in the calculation of these amounts are included in Note 8 to the consolidated financial statements included in the 2018our 2021 Annual Report on Form 10-K.
(4)(2)The amount reported reflectsamounts included in the “Stock awards” column reflect the aggregate grant date fair value of performancerestricted stock units issued to Dr. Tung and Ms. Stuartgranted during fiscal year 2017,the years indicated, calculated in accordance with FASB ASC Topic 718. Such aggregate grant date fair values do not take into account any estimated forfeitures related to service-vesting conditions. The amounts reported in this column reflect the accounting cost for these stock awards and do not correspond to the actual economic value that may be received by the named executive officer upon vesting of the stock awards. Assumptions used in the calculation of this amountthese amounts are included in Note 8 to the consolidated financial statements included in the 2018our 2021 Annual Report on Form 10-K. The grant date fair value of the award represents the value of the performance stock units assuming the maximum achievement of the performance conditions.
(5)
Consists of(3)
The amounts included in the “Non-equity incentive plan compensation” column represent cash bonuses earned under our 2018 and 2017 executive bonus programs with respect tofor the years indicated. See the “Narrative to Summary Compensation Table” below for a description of the 2018 executive bonus program.
(6)
Amounts disclosed under(4)
The amounts included in the “All other compensation” column “All Other Compensation” for 2018 represent Company matching contributions to 401(k) accounts and Concert-paid life insurance premiums.

(5)Mr. Becker was not a named executive officer for the fiscal year ended December 31, 2020, but is a named executive officer for the fiscal year ended December 31, 2021.
Narrative to Summary Compensation Table
We review compensation annually for all employees, including our executives.executive officers. In setting executive officer base salaries and target incentive bonus levels, determining actual incentive bonus amounts and granting equity incentive awards, we consider compensation for comparable positions in the market, the historical compensation levels of our executives,executive officers, individual performance as compared to our expectations and objectives, our desire to motivate our employeesexecutive officers to achieve short- and long-term results that are in the best interests of our stockholders, the highly competitive market for biotechnology executives and a long-term commitment to our Company.Concert. We do not target a specific competitive position or a specific mix of compensation among base salary, bonus or long-term incentives.
21



Our compensation committee has primary responsibility for determining the compensation of our executive officers.officers other than our chief executive officer. Our Board has primary responsibility for determining the compensation of our chief executive officer based on the recommendation of our compensation committee. Our compensation committee typically reviews and discusses proposed compensation with theour chief executive officer for all executivesexecutive officers other than for the chief executive officer. The compensation committee, without the applicable members of management present, discusses recommendations for management and ultimately approves the compensation of our executive officers.himself. During 2018,2021, our compensation committee engaged Radford as its independent compensation consultant to review our executive compensation peer group and program design and to assist with assessing our executives’executive officers’ compensation relative to those at comparable companies. Our compensation committee considered the relationship that Radford has with us, the members of our Board of Directors and our executive officers. Based on the committee’s evaluation, the compensation committee has determined that Radford is independent and that theirits work has not raised any conflicts of interest.

Radford assisted the compensation committee in conducting a competitive compensation assessment for our executive officers for the fiscal year ended December 31, 2018.2021. In evaluating the total compensation of our executive officers, the compensation committee, with the assistance of Radford, reviewed compensation information from our peer group companies. Radford then supplemented the peer group proxy information with published survey data, which provided a broader market representation of companies and deeper position reporting.

Using information provided by Radford, the compensation committee established a peer group of publicly traded companies in the biopharmaceutical and biotechnology industries that is selected based on a balance of the following criteria:

companies whose number of employees, stage of development and market capitalization are similar, though not necessarily identical, to ours;
companies with similar executive positions to ours;
companies against which we believe we compete for executive talent; and
public companies based in the United States whose compensation and financial data are available in proxy statements or through widely available compensation surveys.

Based on these criteria, our peer group for 2018 was comprised of the following 18 publicly traded companies:
Achillion Pharmaceuticals, Inc.CytokineticsMirati Therapeutics, Inc.
Agenus, Inc.Epyzime, Inc.Ovid Therapeutics, Inc.
Akebia Therapeutics, Inc.Geron CorporationRa Pharmaceuticals, Inc.
Ardelyx, Inc.GlycoMimetics, Inc.Sangamo Biosciences, Inc.
Athersys, Inc.Inovio Pharmaceuticals, Inc.Selecta Biosciences, Inc.
ChemoCentryx, Inc.Minerva Neurosciences, Inc.Ziopharm Oncology, Inc.

Base salary. In 2018, the base salaries for Dr. Tung, Ms. Stuart and Mr. Becker were $535,511, $412,186 and $375,682, respectively. We use base salaries to recognize the experience, skills, knowledge and responsibilities required of all our employees, including our named executive officers. None of our named executive officers is currently party to an employment agreement or other agreement or arrangement that provides for automatic or scheduled increases in base salary. In December 2021 and January 2022, our compensation committee, and our Board with respect to our chief executive officer, reviewed the base salaries for our named executive officers and approved a 3.5% increase for 2022 for each named executive officer based on their overall performance in 2021 and their increased level of experience, and to ensure that their salaries remained competitive with those of similarly situated executives in our peer group. The 2021 and 2022 base salaries for our named executive officers are set forth in the following table.
Name
2021 Base Salary
($)

2022 Base Salary
($)
Roger D. Tung599,426620,406
Marc A. Becker428,595443,595
James V. Cassella464,152480,397
Annual bonus. Pursuant to our executive bonus program for 2018,2021, our Board of Directors established and approved annual bonus targets based on the achievement of specified corporate goals. The target bonus amounts for the named executive officers were 50% of base salary for Dr. Tung and 40% of base salary for each of Ms. Stuart and Mr. Becker. OurFor 2021, our corporate goals are typicallywere generally focused on the achievement of specific research, clinical, regulatory,pipeline and financial goals, with an emphasis on advancing our clinical trials and strategic goals.raising additional capital. We considerconsidered these to be difficult to attain, conducive to the creation of stockholder value and designed to contribute to our current and future financial success.  The corporate goals for 2018 were to identify new candidate compounds, advance our CTP-543 and CTP-692 programs, and raise capital.
In January 2019, the2022, our compensation committee and Board conducted a review to determine and approve the attainment of such corporate goals and to assess the individual performance of each of our named executive officers. Based uponon such review and assessment and the

recommendation of our compensation committee, our Board determined that we had overachieved on our corporate goals at a level of 111.5% of target, primarily due to the substantial advancement of our clinical trials. In addition, our Board determined that Dr. Tung’s individual performance had been at a level of 100% of target, that Mr. Becker’s individual performance had been at a level of 125% of target due to his leadership with respect to corporate strategy and fundraising and that Dr. Cassella’s individual performance had been at a level of 125% of target due to his success in progressing our clinical trials during the coronavirus (COVID-19) pandemic. To determine the bonus amounts, the corporate achievement level was multiplied by the individual achievement level. As such, our Board approved cash incentive bonusesbonus payments for each of $300,421 to Dr. Tung, $168,172 to Ms. Stuartour named executive officers for 2021, which are set forth in the following table together with the target bonus amounts (as a percentage of base salary) and $155,040 to Mr. Becker for 2018.the actual achievement of corporate goals and individual performance (as a percentage of target).
Name
2021 Target Bonus
(%)
Achievement of 2021 Corporate Goals (%)2021 Individual Performance (%)

2021 Actual Bonus
($)
 Roger D. Tung55111.5100

367,598
 Marc A. Becker40111.5125

238,942
 James V. Cassella40111.5125

258,765
22



Equity incentives. Although we do not have a formal policy with respect to the grant of equity incentive awards to our executive officers, or any formal equity ownership guidelines applicable to them, we believe that equity grants provide our executivesexecutive officers with a strong link to our long-term performance, create an ownership culture and help to align the interests of our executivesexecutive officers and our stockholders. We typically grant equity awards with a time-based vesting feature. We believe that such awards are inherently performance-based because the value realized by our executive officers, if any, is directly tied to the appreciation of our stock. In addition, we believe that equity grantsawards with a time-based vesting feature promote executive retention because this feature incentivizes our executive officers to remain in our employment during the vesting period. Accordingly, we
We typically grant stock option awards at the start of employment to each executive officer and our other employees, and our compensation committee and Board of Directors periodically review the equity incentive compensation of our named executive officers and other employees, and from time to time, may grant equity incentive awards to them.
For stock options, the option exercise price is equal to the fairclosing market valueprice of our common stock on the date of grant. Time vested stockStock option grants made in connection with the commencement of employment with us typically vest 25% on the first anniversary of the date of grant or, if earlier, the initial employment date (the "vesting commencement date"), and 6.25% vest per quarterin equal quarterly installments thereafter through the fourth anniversary of the vesting commencementinitial employment date. Other stock option grants generallytypically vest 6.25% per quarterin equal quarterly installments through the fourth anniversary of the vesting commencement date.date of grant.
Restricted stock units typically vest in equal annual installments through the third anniversary of the date of grant.
In January 2018, we2021, our Board granted each of Dr. Tung, Ms. Stuart and Mr. Beckerour named executive officers an option to purchase 200,000, 70,000 and 100,000the number of shares of our common stock respectively. The vesting conditions applicable to suchas set forth in the following table and restricted stock units are describedas set forth in the footnotes to the "Outstanding Equity Awards at 2018 Fiscal Year End Table" below.following table.

Name
Number of Shares Subject to Option
(#)

Number of Restricted Stock Units
(#)
 Roger D. Tung205,000

69,300
 Marc A. Becker51,850

21,700
 James V. Cassella60,400

21,700
23




Outstanding Equity Awards at 20182021 Fiscal Year End Table
The following table sets forth information regarding outstanding equity awards held by our named executive officers as of December 31, 2018.2021.

Options awardsStock awards
Name
Number of securities
underlying unexercised
options (#) exercisable
Number of securities
underlying unexercised
options (#) unexercisable
Option
exercise
price ($)
Option
expiration
date
Number of shares or units of stock that have not vested (#)
Market value of shares or units of stock that have not vested
($) (1)
Roger D. Tung203,3008.406/10/2024
170,00016.851/7/2026
200,00010.971/4/2027
187,50012,500(2)27.591/4/2028
137,50062,500(3)13.931/4/2029
66,32585,275(4)10.872/13/2030
38,438166,562(5)13.071/4/2031
67,400(6)212,310
69,300(7)218,295
Marc A. Becker93,7506,250(2)27.591/4/2028
75,62534,375(3)13.931/4/2029
18,56323,867(4)10.872/13/2030
9,72242,128(5)13.071/4/2031
18,810(6)59,252
21,700(7)68,355
James V. Cassella140,00014.463/5/2025
50,00016.851/7/2026
70,00010.971/4/2027
46,4063,094(2)27.591/4/2028
51,56223,438(3)13.931/4/2029
18,56323,867(4)10.872/13/2030
11,32549,075(5)13.071/4/2031
18,810(6)59,252
21,700(7)68,355
 Options Awards Stock Awards
NameNumber of securities
underlying unexercised
options (#) exercisable
Number of securities
underlying unexercised
options (#) unexercisable
 Option
exercise
price ($)
Option
expiration
date
 Number of units of stock that have not vested (#) 
Market value of units of stock that have not vested ($) (9)
Roger D. Tung, Ph.D.38,052

(1)4.41
12/10/2019    
 29,202

(2)3.79
12/14/2020    
 39,822

(3)3.50
12/15/2021    
 203,300

(4)8.40
6/10/2024    
 116,875
53,125
(5)16.85
1/7/2026    
 87,500
112,500
(6)10.97
1/4/2027    
 37,500
162,500
(7)27.59
1/4/2028    
       20,000
(10) 
251,000
Nancy Stuart34,512

(1)4.41
12/10/2019    
 21,238

(2)3.79
12/14/2020    
 22,122

(3)3.50
12/15/2021    
 100,000

(4)8.40
06/10/2024    
 55,000
25,000
(5)16.85
01/07/2026    
 30,625
39,375
(6)10.97
01/04/2027    
 13,125
56,875
(7)27.59
01/04/2028    
       15,000
(10) 
188,250
Marc Becker
100,000
(8)27.59
01/04/2028    

(1)This stock option was granted under our 2006 Stock Option and Grant Plan and was subject to vesting in equal quarterly installments over four years from the vesting start date and fully vested in accordance with its terms on December 10, 2013.
(2)This stock option was granted under our 2006 Stock Option and Grant Plan and was subject to vesting in equal quarterly installments over four years from the vesting start date and fully vested in accordance with its terms on December 14, 2014.
(3)This stock option was granted under our 2006 Stock Option and Grant Plan and was subject to vesting in equal quarterly installments over four years from the vesting start date and fully vested in accordance with its terms on December 15, 2015.
(4)This stock option was granted under our 2014 Stock Incentive Plan and was subject to vesting in equal quarterly installments over four years from the vesting start date and fully vested in accordance with its terms on June 10, 2018.
(5)This option was granted under our 2014 Stock Incentive Plan and vests as to 6.25% of the shares underlying such option at the end of each quarter, through and including January 7, 2020.
(6)This option was granted under our 2014 Stock Incentive Plan and vests as to 6.25% of the shares underlying such option at the end of each quarter, through and including January 4, 2021.
(7)This option was granted under our 2014 Stock Incentive Plan and vests as to 6.25% of the shares underlying such option at the end of each quarter, through and including January 4, 2022.
(8)This option was granted under our 2014 Stock Incentive Plan and vests as to 25% of the shares on January 4, 2019 and vests as to an additional 6.25% of the shares at the end of each successive three-month period through and including January 4, 2022.


(9)Based on the closinga price of $12.55,$3.15, which was the closing market price on NASDAQ of our common stock on the Nasdaq Global Market on December 31, 2018, the last trading day of 2018.2021.
(10)(2)Consists ofThe unvested shares under this option vested in full on January 4, 2022.
(3)The unvested shares under this option are scheduled to vest in equal quarterly installments through January 4, 2023.
(4)The unvested shares under this option are scheduled to vest in equal quarterly installments through February 14, 2024.
(5)The unvested shares under this option are scheduled to vest in equal quarterly installments through January 5, 2025.
(6)These restricted stock units granted on July 6, 2017, whichare scheduled to vest in full on March 31, 2019 assuming that the executive officer remains employed with the Companyequal annual installments through such date.February 14, 2023.
(7)These restricted stock units are scheduled to vest in equal annual installments through January 5, 2024.
Employment Agreements Severance and Change in Control Arrangements
Employment agreements
We have entered into employment agreements with each of our named executive officers. The employment agreements confirm the named executive officers’ titles, compensation arrangements and eligibility for benefits made available to employees generally and also provide for certain benefits upon a termination of employment under specified conditions. Each named executive officer’s employment is at will.
Payments and benefits provided upon a qualifying termination not in connection with a change of control
24



Under the terms of the employment agreements we have entered into with each of theour named executive officers, if anthe executive’s employment is terminated by us other than for "cause"“cause” and other than as a result of death or disability or by such executive officer for "good reason",“good reason,” each as defined in such employment agreement, in each case not within the "change“change of control period",period,” as defined below, and subject to the executive’s execution of an effective general release of potential claims against us, each named executive officer will be entitled to (1) an amount equal to his or her then-current monthly base salary for a period of 12 months, or 15 months in the case of Dr. Tung, and (2) continued Company paid medical and dental benefits to the extent that the named executive officer was receiving them at the time of termination until the earlier of 12 months following termination, or 15 months following termination in the case of Dr. Tung, and the date the named executive officer’s COBRA continuation coverage expires, subject to certain legal restrictions.to:
Payments and benefits provided upon a qualifying termination in connection with a change of control
An amount equal to 12 months (or 15 months in the case of Dr. Tung) of the named executive officer’s base salary, which will be paid in the form of salary continuation; and
Continued Concert-paid medical and dental benefits to the extent that the named executive officer was receiving them at the time of termination until the earlier of 12 months (or 15 months in the case of Dr. Tung) following termination and the date the named executive officer’s COBRA continuation coverage expires, subject to certain legal restrictions.
Under the terms of the employment agreements we have entered into with each of theour named executive officers, if the executive’s employment is terminated by us or ourany successor other than for cause or by such executive officer for good reason, in each case within one year following a "change“change of control",control,” as defined in such employment agreement (such one-year period, the "changechange of control period"period), and subject to the executive’s execution of an effective general release of potential claims against us, in lieu of the severance benefits described above, each named executive officer will be entitled to:
An amount equal to 12 months (or 18 months in the case of Dr. Tung) of the named executive officer’s base salary, which will be paid as a lump sum if the change of control constitutes a change inof control under Section 409A of the Internal Revenue Code.
Code and otherwise will be paid in the form of salary continuation;
An amount equal his or her current target bonusto one times (or 1.5 times his target bonus in the case of Dr. Tung).
the greater of the named executive officer’s current target bonus or the actual bonus paid to the named executive officer for the immediately preceding calendar year; and
Continued Company paidConcert-paid medical and dental benefits to the named executive officer to the extent that he or she was receiving them at the time of termination until the earlier of 12 months (or 18 months in the case of Dr. Tung) following termination and the date the named executive officer’s COBRA continuation coverage expires, subject to certain legal restrictions.

In addition, if aduring the change of control occurs and within one year following such change of controlperiod, we or ourany successor terminate the executive’snamed executive officer’s employment other than for cause, or the executive’snamed executive officer’s employment ends due to the executive'snamed executive officer’s death or disability, or the named executive officer terminates his or her employment for good reason, then all stock options held by the named executive officer will immediately vest in full.

If the payments or benefits payable to any named executive officer in connection with a change of control would be subject to the excise tax imposed under Section 4999 of the Internal Revenue Code, then those payments or benefits will be reduced to the extent necessary to avoid the imposition of such excise tax, but only if such reduction would result in a higher net after-tax benefit to the named executive officer.

The following table summarizes the severance payments and benefits our named executive officers would be entitled to receive, assuming a qualifying termination occurred on December 31, 2018.
Name 
Cash
Severance
($)
(1)
 
Bonus
($)
(2)
 
COBRA
Continuation
($)
(3)
 
Value of
Accelerated
Vesting of Stock Options ($)
(4)
 Total ($)
Roger D. Tung, Ph.D.          
Qualifying termination not in connection with a change of control 669,389
 
 37,965
 
 707,354
Qualifying termination in connection with a change of control 803,267
 401,633
 45,558
 177,750
 1,428,208
Nancy Stuart          
Qualifying termination not in connection with a change of control 412,186
 
 28,536
 
 440,722
Qualifying termination in connection with a change of control 412,186
 164,874
 28,536
 62,213
 667,809
Marc Becker          
Qualifying termination not in connection with a change of control 375,682
 
 30,606
 
 406,288
Qualifying termination in connection with a change of control 375,682
 150,273
 30,606
 
 556,561
(1)
For a termination by us other than for cause and other than as a result of death or disability or by the executive for good reason, in each case not during the change of control period, this amount represents, in the case of Dr. Tung, 15 months of base salary, and in the case of Ms. Stuart and Mr. Becker, 12 months of base salary, each at the rate in effect on December 31, 2018.

In the event of a termination by us other than for cause or by the executive for good reason, in each case within 12 months of a change of control, this amount represents, in the case of Dr. Tung, 18 months base salary, and in the case of Ms. Stuart and Mr. Becker, 12 months of base salary, each at the rate in effect on December 31, 2018.
(2)In the event of a termination by us other than for cause or by the executive for good reason, in each case during the change of control period, amounts represent in the case of Dr. Tung, 150% of his target bonus for 2018, and in the case of Ms. Stuart and Mr. Becker, 100% of the applicable executive’s target bonus for 2018.
(3)This amount represents the Company-paid health and dental coverage. In the case of Dr. Tung, the amounts represent 15 months of coverage payable following a termination by us other than for cause and other than as a result of death or disability or by him for good reason, in each case not during the change of control period, and represents 18 months payable following a termination by us other than for cause or by him for good reason, in each case during the change of control period. With respect to Ms. Stuart and Mr. Becker, amounts represent 12 months of Company-paid health and dental coverage.
(4)In the event of a termination by us other than for cause, termination due to death or disability or a termination by the executive for good reason, in each case during the change of control period, all unvested stock options held by the executive at such time will immediately vest in full. The values for the accelerated vesting of stock options included in the table above are based on the intrinsic values of such unvested awards on December 31, 2018 (i.e., the difference between the closing price of the Company’s common stock on the NASDAQ Global Market on that date and the applicable exercise price, multiplied by the number of shares for which vesting would have been accelerated).
Other agreementsAgreements
We have also entered into employee confidentiality, non-competition and proprietary information agreements with each of our named executive officers. Under the employee confidentiality, non-competition and proprietary information agreements, each named executive officer has agreed (1) not to compete with us during his or her employment and for a period of one year after the termination of his or her employment, (2) not to solicit our employees during his or her employment and for a period of

one year after the termination of his or her employment, (3) to protect our confidential and proprietary information and (4) to assign to us related intellectual property developed during the course of his or her employment.
401(k) retirement planRetirement Plan
We maintain a 401(k) retirement plan that is intended to be a tax-qualified defined contribution plan under Section 401(k) of the Internal Revenue Code. In general, all of our employees are eligible to participate, beginning on the first day of the month following commencement of their employment. The 401(k) plan includes a salary deferral arrangement pursuant to which participants may elect to reduce their current compensation by up to the statutorily prescribed limit, equal to $18,500$19,500 in 2018,2021, and have the amount of the reduction contributed to the 401(k) plan. Participants over the age of 50 are entitled to an additional catch-up contribution up to the statutorily prescribed limit, equal to $6,000$6,500 in 2018.2021. Currently, we match 50% of employee contributions up to 6% of the employee’s salary, subject to the statutorily prescribed limit, equal to $8,250$8,700 in 2018.2021. The match immediately vests in full.
25



Securities Authorized for Issuance Under Equity Compensation Plans
The following table provides information about the securities authorized for issuance under our equity compensation plans as of December 31, 2018.2021.
Plan categoryNumber of securities to be issued upon exercise of outstanding options, warrants and rightsWeighted-average exercise price of outstanding options, warrants and rightsNumber of securities remaining available for future issuance under equity compensation plans (excluding securities reflected in column (a))
(a)(b)(c)
Equity compensation plans approved by security holders 5,825,512(1)$14.21 1,463,441(2)
Equity compensation plans not approved by security holders
Total5,825,512$14.211,463,441
Plan category Number of
securities to be
issued upon exercise
of outstanding
options, warrants
and rights
 Weighted-average
exercise price of
outstanding options,
warrants and rights
 Number of securities
remaining available
for future issuance
under equity
compensation plans
(excluding securities
reflected in column (a))
 
  (a) (b) (c) 
Equity compensation plans approved by security holders 3,785,556
(1)$15.26
 1,488,976
(2)
Equity compensation plans not approved by security holders 
 
 
 
Total 3,785,556
 $15.26
 1,488,976
 

(1)
Consists of stock options and restricted stock units outstanding as of December 31, 20182021 under our Amended and Restated 2006 Stock Option and Grant Plan (the “2006 Plan”) and our 2014 Stock Incentive Plan which we refer to as the 2006 Plan and the (the “2014 Plan respectively.”).
(2)
Consists of shares of common stock authorized under the 2014 Plan that remained available for grant under future awards as of December 31, 2018.2021. This amount does not include an additional 937,5031,389,561 shares that became available for issuance under the 2014 Plan on January 1, 20192022 in accordance with the terms of the 2014 Plan. The number of shares available under the 2014 Plan is subject to further increase by (i) the number of shares of our common stock subject to outstanding awards under the 2006 Plan that expire, terminate or are otherwise surrendered, cancelled, forfeited or repurchased and (ii) further annual increases, to be added on January 1 of each year, through 2024, in each case equal to the lowest of (a) 2,000,000 shares of our common stock, (b) 4% of the number of our outstanding shares on January 1 of each such fiscal year and (c) an amount determined by our Board of Directors.
Board.

26

PRINCIPAL STOCKHOLDERS



STOCK OWNERSHIP AND REPORTING
Security Ownership of Certain Beneficial Owners and Management
The following table sets forth information, to the extent known by us or ascertainable from public filings, with respect to the beneficial ownership of our common stock as of March 31, 20192022 by:
each of our directors and our director nominees;
each of our named executive officers;
all of our directors, our director nominees and executive officers as a group; and
each person, or group of affiliated persons, who is known by us to beneficially own more than 5% of our common stock.stock;
each of our named executive officers;
each of our directors and director nominees; and
all of our executive officers and directors as a group.
Beneficial ownership is determined in accordance with the rules and regulations of the SEC. These rules generally attribute beneficial ownership of securities to persons who possess sole or shared voting power or investment power with respect to those securities and include shares of common stock issuable upon the exercise of stock options that are immediately exercisable or exercisable within 60 days after March 31, 2019.2022 and restricted stock units that are scheduled to vest within 60 days after March 31, 2022. Except as otherwise indicated, to our knowledge, all of the shares reflected in the table are shares of common stock and all persons listed below have sole voting and investment power with respect to the shares beneficially owned by them, subject to community property laws, where applicable. The information is not necessarily indicative of beneficial ownership for any other purpose.
The percentage ownership calculations for beneficial ownership are based on 23,756,80134,953,342 shares of common stock outstanding as of March 31, 2019.2022. Except as otherwise indicated in the table below, addressesthe address of namedeach beneficial owners are in care ofowner is c/o Concert Pharmaceuticals, Inc., 65 Hayden Avenue, Suite 3000N, Lexington, MassachusettsMA 02421.
In computing the number of shares of common stock beneficially owned by a person and the percentage ownership of that person, we deemed outstanding any shares of common stock subject to options held by that person that are currently exercisable or are exercisable within 60 days after March 31, 2019. We2022 and restricted stock units held by that person that are scheduled to vest within 60 days after March 31, 2022. However, we did not deem these shares outstanding however, for the purposepurposes of computing the percentage ownership of any other person.
27



Name of beneficial owner Number of
shares
beneficially
owned
 Percentage
of shares
beneficially
owned
5% Stockholders    
Entities affiliated with Perceptive Advisors, LLC (1)
 1,873,779
 7.9%
Entities affiliated with RTW Investments, LP (2)
 1,811,662
 7.6%
Entities affiliated with BlackRock Inc.(3)
 1,700,485
 7.2%
Entities affiliated with BVF (4)
 1,381,845
 5.8%
Ingalls & Snyder LLC (5)
 1,199,775
 5.1%
Entities affiliated with GlaxoSmithKline (6)
 1,179,941
 5.0%
   
Executive Officers and Directors    
Roger D. Tung, Ph.D.(7)
 1,375,570
 5.6%
Nancy Stuart (8)
 379,037
 1.6%
Marc Becker (9)
 38,125
 *
Richard H. Aldrich (10)
 423,281
 1.8%
Thomas G. Auchincloss (11)
 66,500
 *
Ronald W. Barrett, Ph.D.(12)
 37,500
 *
Christine van Heek (13)
 40,417
 *
Peter Barton Hutt, LL.M (14)
 56,080
 *
Wilfred E. Jaeger, M.D.(15)
 37,500
 *
Wendell Wierenga, Ph.D.(16)
 77,677
 *
All current executive officers and directors as a group (11 persons) (17)
 2,793,008
 11.0%
Name of Beneficial Owner
Number of
Shares of Common Stock
Beneficially
Owned
Percentage
of Shares of Common Stock
Beneficially
Owned
5% Stockholders
Entities affiliated with Perceptive Advisors LLC (1)
3,950,64110.75%
Entities affiliated with BVF Partners L.P. (2)
3,629,3349.99%
Entities affiliated with RA Capital Healthcare Fund, L.P. (3)
3,542,6979.99%
Named Executive Officers and Directors
Roger D. Tung (4)
1,924,1325.34%
Marc A. Becker (5)
262,985*
James V. Cassella (6)
468,6301.33%
Richard H. Aldrich (7)
490,8501.40%
Thomas G. Auchincloss, Jr. (8)
99,188*
Ronald W. Barrett (9)
67,688*
Jesper Høiland (10)
40,605*
Peter Barton Hutt (11)
79,190*
Wilfred E. Jaeger (12)
67,688*
Christine van Heek (13)
86,832*
All executive officers and directors as a group (12 persons) (14)
4,276,24511.33%

*Represents beneficial ownership of less than 1% of our outstanding stock.common stock as of March 31, 2022.

(1)
Consists of (i) 2,150,641 shares of common stock and (ii) 1,800,000 shares of common stock underlying a warrant that is exercisable as of March 31, 2022. Based on information set forth in a Schedule 13G13G/A filed with the Securities and Exchange CommissionSEC on February 14, 2019 by the following entities and individual. Consists of 1,873,779 shares of common stock beneficially owned by2022. Perceptive Life Sciences Master Fund, LTDLtd. (the "Master Fund"Master Fund). directly holds 2,150,641 shares of common stock. Perceptive Advisors LLC ("(“Perceptive Advisors"Advisors) serves as the investment manager to the Master Fund and may be deemed to beneficially own the securities directly held by the Master Fund. Joseph Edelman ("(“Mr. Edelman"Edelman) is the managing member of Perceptive Advisors and may be deemed to beneficially own the securities directly held by the Master Fund. The address for the Master Fund, Perceptive Advisors and Mr. Edelman is 51 Astor Place, 10th Floor, New York, NY 10003.
28



(2)Based on information set forth in a Schedule 13G filed with the Securities and Exchange Commission on March 25, 2019 by the following entities and individual.
Consists of 1,811,662(i) 2,253,000 shares of common stock held by RTW Master Fund, Ltd. and one or more private funds (together the “Funds”) managed by RTW Investments, LP (the “Adviser”). The Adviser, in its capacity as the investment manager(ii) 1,376 shares of the Funds, has the powerSeries X1 preferred stock that are eligible to vote and the power to direct the disposition of all Shares held by the Funds. Accordingly, for the purposes of Reg. Section 240.13d-3, the Adviser may be deemed to beneficially own an aggregate of 1,811,662 Shares. Roderick Wong is the Managing Partner of the Adviser. The address for the Adviser and Mr. Wong is 412 West 15th Street, Floor 9, New York, NY 10011, the address for RTW Master Fund, Ltd is 190 Elgin Avenue, George Town, Grand Cayman KY1-9001, Cayman Islands.
(3)Based on information set forth in a Schedule 13G filed with the Securities and Exchange Commission on February 4, 2018 by BlackRock, Inc. Consists of 1,700,485converted into 1,376,000 shares of common stock as of March 31, 2022. In addition, entities affiliated with BVF Partners L.P. (“Partners”) hold (i) 5,121 shares of Series X1 preferred stock that are not eligible to be converted into common stock as of March 31, 2022 (the “Additional BVF Shares”) and (ii) warrants to purchase an aggregate of 8,750 shares of Series X1 preferred stock (the “BVF Warrant Shares”). The Additional BVF Shares and, upon exercise of the warrants, the BVF Warrant Shares are not eligible to be converted into common stock as of March 31, 2022 due to a conversion limitation that prevents entities affiliated with Partners from converting Series X1 preferred stock to common stock if, after such conversion, entities affiliated with Partners would beneficially owned by BlackRock, Inc. The address for BlackRock, Inc. is 55 East 52nd Street, New York, NY, 10055.

own more than 9.99% of the outstanding shares of common stock (the “BVF Conversion Limitation”). In the absence of the BVF Conversion Limitation, the Additional BVF Shares and, upon exercise of the warrants, the BVF Warrant Shares would be convertible into an aggregate of 13,871,000 shares of common stock.
(4)
Based on information set forth in a Schedule 13G filed with the Securities and Exchange CommissionSEC on February 7, 2019 by the following entities and individual. Consists of (i) 664,843 shares of common stockNovember 15, 2021. The reported securities are beneficially owned by Biotechnology Value Fund, L.P. (“BVF”BVF), (ii) 545,841 shares of common stock beneficially owned by Biotechnology Value Fund II, L.PL.P. (“BVF2”BVF2) and (iii) 96,323 shares of common stock beneficially owned by Biotechnology Value Trading Fund OS LP (“Trading Fund OS”OS). BVF I GP LLC (“BVF GP”), as the general partner of BVF, may be deemed to beneficially own the reported securities beneficially owned by BVF. BVF II GP LLC (“BVF2 GP”), as the general partner of BVF2, may be deemed to beneficially own the reported securities beneficially owned by BVF2. BVF Partners OS Ltd. (“(Partners OS”), as the general partner of Trading Fund OS, may be deemed to beneficially own the 96,323 shares of Common Stockreported securities beneficially owned by Trading Fund OS. BVF Partners L.P.GP Holdings LLC (“Partners”BVF GPH), as the sole member of each of BVF GP and BVF2 GP, may be deemed to beneficially own the reported securities beneficially owned in the aggregate by BVF and BVF2. Partners, as the general partner of BVF, BVF2, the investment manager of Trading Fund OS, and the sole member of Partners OS, may be deemed to beneficially own the 1,381,845 shares of Common Stockreported securities beneficially owned in the aggregate by BVF, BVF2 and Trading Fund OS, and certain Partners management accounts (the “Partners Management Accounts”), including 74,838 shares of Common Stock held in the Partners Managed Accounts.OS. BVF Inc., as the investment adviser and general partner of Partners, may be deemed to beneficially own the 1,381,845 shares of Common Stockreported securities beneficially owned by Partners. Mark Lampert (“Mr. Lampert”), as a director and officer of BVF Inc., may be deemed to beneficially own the 1,381,845 shares of Common Stockreported securities beneficially owned by BVF Inc. The foregoing should not be construed in and of itself as an admission by any of the forgoing entities or individuals as to beneficial ownership of any reported securities owned by another entity or individual. BVF GP disclaims beneficial ownership of the reported securities beneficially owned by BVF. BVF2 GP disclaims beneficial ownership of the reported securities beneficially owned by BVF2. Partners OS disclaims beneficial ownership of the shares of Common Stockreported securities beneficially owned by Trading Fund OS. BVF GPH disclaims beneficial ownership of the reported securities beneficially owned by BVF and BVF2. Each of Partners, BVF Inc. and Mr. Lampert disclaims beneficial ownership of the shares of Common Stockreported securities beneficially owned by BVF, BVF2 and Trading Fund OS, and the filing of the Schedule 13G shall not be construed as an admission that any such person or entity is the beneficial owner of any such securities. The address for Partners, Management Accounts.BVF, BVF2, BVF GP, BVF2 GP, BVF GPH, BVF Inc. and Mr. Lampert is 44 Montgomery Street, 40th Floor, San Francisco, CA 94104. The address for Trading Fund OS and Partners OS is POP.O. Box 309 Ugland House, Grand Cayman, KY1-1104, Cayman Islands and the address for each of the other entities and for Mr. Lampert is 44 Montgomery Street, 40th Floor, San Francisco, CA 94104.Islands.
29



(5)Based on information set forth in a Schedule 13G filed with the Securities and Exchange Commission on January 30, 2019 by Ingalls & Snyder LLC.
(3)
Consists of 1,199,775(i) 3,033,603 shares of common stock beneficially owned by Ingalls & Snyder LLC.and (ii) 509 shares of Series X1 preferred stock that are eligible to be converted into 509,000 shares of common stock as of March 31, 2022. In addition, RA Capital Healthcare Fund, L.P. (the “Fund”) holds (i) 6,991 shares of Series X1 preferred stock that are not eligible to be converted into common stock as of March 31, 2022 (the “Additional RA Shares”) and (ii) warrants to purchase an aggregate of 7,500 shares of Series X1 preferred stock (the “RA Warrant Shares”). The address for Ingalls & Snyder LLC is 1325 AvenueAdditional RA Shares and, upon exercise of the Americas, New York, NY, 10019.
(6)warrants, the RA Warrant Shares are not eligible to be converted into common stock as of March 31, 2022 due to a conversion limitation that prevents the Fund from converting Series X1 preferred stock to common stock if, after such conversion, entities affiliated with the Fund would beneficially own more than 9.99% of the outstanding shares of common stock (the “RA Conversion Limitation”). In the absence of the RA Conversion Limitation, the Additional RA Shares and, upon exercise of the warrants, the RA Warrant Shares would be convertible into an aggregate of 14,491,000 shares of common stock.

Based on information set forth in a Schedule 13G13G/A filed with the Securities and Exchange CommissionSEC on February 13, 201814, 2022. RA Capital Healthcare Fund GP, LLC is the general partner of the Fund. The general partner of RA Capital Management, L.P. (“RA Capital”) is RA Capital Management GP, LLC, of which Peter Kolchinsky (“Dr. Kolchinsky”) and Rajeev Shah (“Mr. Shah”) are the controlling persons. RA Capital serves as investment adviser for the Fund and may be deemed a beneficial owner, for purposes of Section 13(d) of the Exchange Act, of any securities held by GlaxoSmithKline plc. the Fund. The Fund has delegated to RA Capital the sole power to vote and the sole power to dispose of all securities held in the Fund’s portfolio, including the reported securities. Because the Fund has divested voting and investment power over the reported securities it holds and may not revoke that delegation on less than 61 days’ notice, the Fund disclaims beneficial ownership of the securities it holds for purposes of Section 13(d) of the Exchange Act. As managers of RA Capital, Dr. Kolchinsky and Mr. Shah may be deemed beneficial owners, for purposes of Section 13(d) of the Exchange Act, of any reported securities beneficially owned by RA Capital. RA Capital, Dr. Kolchinsky and Mr. Shah disclaim ownership of the reported securities other than for the purpose of determining their obligations under Section 13(d) of the Exchange Act, and the filing of the Schedule 13G/A shall not be deemed an admission that either RA Capital, Dr. Kolchinsky or Mr. Shah is the beneficial owner of the reported securities for any other purpose. The address for the Fund, RA Capital, Dr. Kolchinsky and Mr. Shah is 200 Berkeley Street, 18th Floor, Boston, MA 02116.

(4)Consists of 1,179,941(i) 691,458 shares of common stock held by Glaxo Group Limited, a wholly owned subsidiary of GlaxoSmithKline plc. The address of these entities is 980 Great West Road, Brentford, Middlesex, United Kingdom TW8 9GS.
(7)In addition to shares of common stock held directly, includesDr. Tung, (ii) 121,873 shares of common stock held by the Roger D. Tung 2011 GRAT, forof which Dr. Tung is the sole trustee, (iii) 12,389 shares of common stock held by the RD Tung Irrevocable Trust, forof which Dr. Tung’s wife is a co-trustee, and(iv) 13,274 shares of common stock held by the Tung Family Investment Trust, forof which Dr. Tung is a co-trustee. Includes 636,001co-trustee, and (v) 1,085,138 shares of common stock issuable upon the exerciseunderlying options that are exercisable as of optionsMarch 31, 2022 or will become exercisable within 60 days after such date.
(5)Consists of (i) 33,540 shares of common stock and (ii) 229,445 shares of common stock underlying options that are exercisable as of March 31, 2019.2022 or will become exercisable within 60 days after such date.
(8)(6)In addition toConsists of (i) 55,451 shares of common stock and (ii) 413,179 shares of common stock underlying options that are exercisable as of March 31, 2022 or will become exercisable within 60 days after such date.
(7)Consists of (i) 336,975 shares of common stock held directly, includes 280,194 shares of common stock issuable upon the exercise of options exercisable within 60 days after March 31, 2019.
(9)Consists of 38,125 shares of common stock issuable upon exercise of options exercisable within 60 days after March 31, 2019.
(10)In addition to shares of common stock held directly, includesby Mr. Aldrich, (ii) 44,351 shares of common stock held by the Little Eagles, LLC, of which the owners of Little Eagles, LLC are the Richard H. Aldrich Irrevocable Trust of 2011 and trusts established for the benefit of the Mr. Aldrich'sAldrich’s minor children.children, and (iii) 109,524 shares of common stock underlying options that are exercisable as of March 31, 2022 or will become exercisable within 60 days after such date. The trustees of the Richard H. Aldrich Irrevocable Trust of 2011 are Mr. Aldrich's spouse, Nichole A. Aldrich,Aldrich’s wife and Mr. Aldrich's brother, Caleb F. Aldrich.Aldrich’s brother. The beneficiaries of the Richard H. Aldrich Irrevocable Trust of 2011 are Mr. Aldrich'sAldrich’s minor children. Mr. Aldrich disclaims beneficial ownership of suchthe shares held by the Richard H. Aldrich Irrevocable Trust of 2011, except to the extent of any pecuniary interest therein. Includes 41,955
(8)Consists of (i) 6,500 shares of common stock issuable upon the exerciseand (ii) 92,688 shares of common stock underlying options that are exercisable as of March 31, 2022 or will become exercisable within 60 days after March 31, 2019.such date.
(11)(9)In addition toConsists of 67,688 shares of common stock held directly, includes 62,500 sharesunderlying options that are exercisable as of common stock issuable upon the exercise of optionsMarch 31, 2022 or will become exercisable within 60 days after such date.
(10)Consists of 40,605 shares of common stock underlying options that are exercisable as of March 31, 2019.2022 or will become exercisable within 60 days after such date.
(11)Consists of (i) 7,963 shares of common stock and (ii) 71,227 shares of common stock underlying options that are exercisable as of March 31, 2022 or will become exercisable within 60 days after such date.
30



(12)Consists of 37,50067,688 shares of common stock issuable upon the exerciseunderlying options that are exercisable as of optionsMarch 31, 2022 or will become exercisable within 60 days after March 31, 2019.such date.
(13)Consists of 40,417(i) 10,000 shares of common stock issuable upon the exerciseand (ii) 76,832 shares of common stock underlying options that are exercisable as of March 31, 2022 or will become exercisable within 60 days after March 31, 2019.such date.
(14)In addition to shares held directly, includes 51,656Consists of (i) 1,484,150 shares of common stock issuable upon the exerciseand (ii) 2,792,095 shares of common stock underlying options that are exercisable as of March 31, 2022 or will become exercisable within 60 days after March 31, 2019.
(15)Consists of 37,500 shares of common stock issuable upon the exercise of options exercisable within 60 days after March 31, 2019.
(16)In addition to shares held directly, includes 66,038 shares of common stock issuable upon the exercise of options exercisable within 60 days after March 31, 2019.
(17)Includes 1,532,042 shares of common stock issuable upon the exercise of options exercisable within 60 days after March 31, 2019.


CERTAIN RELATIONSHIPS AND RELATED PERSON TRANSACTIONS
Policies and Procedures for Related Person Transactions
Our Board has adopted a written related person transaction policy that sets forth policies and procedures for the review and approval or ratification of related person transactions. This policy covers any transaction, arrangement or relationship, or any series of similar transactions, arrangements or relationships, in which we were or are to be a participant, the amount involved exceeds $120,000, and a related person had or will have a direct or indirect material interest, including, without limitation, purchases of goods or services by or from the related person or entities in which the related person has a material interest, indebtedness, guarantees of indebtedness and employment by us of a related person.
Our related person transaction policy contains exceptions for any transaction or interest that is not considered a related person transaction under SEC rules as in effect from time to time. In addition, the policy provides that an interest arising solely from a related person’s position as an executive officer of another entity that is a participant in a transaction with us will not be subject to the policy if each of the following conditions is met:
the related person and all other related persons own in the aggregate less than a 10% equity interest in such entity;date.
31
the related person and his or her immediate family members are not involved in the negotiation of the terms of the transaction with us and do not receive any special benefits as a result of the transaction; and



the amount involved in the transaction equals less than the greater of $200,000 or 5% of the annual gross revenue of the company receiving payment under the transaction.
PROPOSAL NO. 2 – NON-BINDING, ADVISORY VOTE ON EXECUTIVE COMPENSATION
The policy provides that any related person transaction proposedWe are providing our stockholders the opportunity to be entered into by us must be reportedvote to approve, on a non-binding, advisory basis, the compensation of our general counsel and will be reviewed and approved by our audit committeenamed executive officers as disclosed in this proxy statement in accordance with the termsSEC’s rules. This proposal, which is commonly referred to as “say-on-pay,” is required by the Dodd-Frank Wall Street Reform and Consumer Protection Act of 2010, which added Section 14A to the policy, prior to effectiveness or consummation ofExchange Act. Consistent with the transaction whenever practicable. The policy provides that ifpreference expressed by our chief financial officer determines that advance approval of a related person transaction is not practicable under the circumstances,stockholders at our audit committee will review and, in its discretion, may ratify the related person transaction at the next2020 annual meeting of the audit committee. The policy also provides that alternatively,stockholders, we have determined to hold a non-binding, advisory vote on executive compensation annually.
Our executive compensation program is designed to attract, motivate and retain our chief financial officer may present a related person transaction arising in the time period between meetings of the audit committee to the chair of the audit committee, who will review and may approve the related person transaction, subject to ratification by the audit committee at the next meeting of the audit committee.
In addition, the policy provides that any related person transaction previously approved by the audit committee or otherwise already existing that is ongoing in nature will be reviewed by the audit committee annually to ensure that such related person transaction has been conducted in accordance with the previous approval granted by the audit committee, if any, and that all required disclosures regarding the related person transaction are made.
The policy provides that transactions involving compensation ofnamed executive officers, will be reviewedwho are critical to our success. Under this program, our named executive officers are rewarded for the achievement of our short- and approvedlong-term financial and strategic goals and for driving corporate financial performance and stability. The program contains elements of cash and equity-based compensation and is designed to align the interests of our named executive officers with those of our stockholders. We believe that our compensation program strikes an appropriate balance between the implementation of responsible, measured compensation practices and the effective provision of incentives for our named executive officers to exert their best efforts for our success.
The “Executive Compensation” section of this proxy statement describes our executive compensation program and the decisions made by our compensation committee inand our Board with respect to the manner to be specified inyear ended December 31, 2021. Our executive compensation program embodies a pay-for-performance philosophy that supports our business strategy and aligns the charterinterests of our named executive officers with our stockholders. Our Board believes that this link between compensation and the compensation committee.
A related person transaction reviewed under this policy will be considered approved or ratified if it is authorizedachievement of our short- and long-term business objectives has helped drive our performance over time. At the same time, we believe that our program does not encourage excessive risk-taking by the audit committee in accordance with the standards set forth in the policy after full disclosure of the related person’s interests in the transaction. As appropriate for the circumstances, the policy provides that the audit committee will review and consider:
the related person’s interest in the related person transaction;
the approximate dollar value of the amount involved in the related person transaction;
the approximate dollar value of the amount of the related person’s interest in the transaction without regard to the amount of any profit or loss;
whether the transaction was undertaken in the ordinary course of business of the Company;
whether the transaction with the related person is proposed to be, or was, entered into on terms no less favorable to us than the terms that could have been reached with an unrelated third party;

the purpose of, and the potential benefits to us of, the transaction; and
any other information regarding the related person transaction or the related person in the context of the proposed transaction that would be material to investors in light of the circumstances of the particular transaction.
The policy provides that the audit committee will review all relevant information available to it about the related person transaction. The policy provides that the audit committee may approve or ratify the related person transaction only if the audit committee determines that, under all of the circumstances, the transaction is in, ormanagement. This vote is not inconsistent with,intended to address any specific item of compensation, but rather the overall compensation of our best interests. The policy provides that the audit committee may, in its sole discretion, impose such conditions as it deems appropriate on us or the related person in connection with approval of the related person transaction.
No related person transactions were brought to the attention of the audit committee for consideration in 2018.



SECTION 16(a) BENEFICIAL OWNERSHIP REPORTING COMPLIANCE
Section 16(a) of the Exchange Act requires our directors,named executive officers and persons holding more than 10%the policies and practices described in this proxy statement.
Our Board is asking stockholders to approve a non-binding, advisory vote on the following resolution:
RESOLVED, that the compensation paid to Concert’s named executive officers, as disclosed pursuant to the compensation disclosure rules of the Company’s common stock to report their initial ownership ofSecurities and Exchange Commission, the common stock and other equity securitiescompensation tables and any changes in that ownership in reports that must be filed with the SEC. The SEC has designated specific deadlines for these reports, and we must identifyrelated material disclosed in this proxy statement, those persons who did not file these reports when due.
Based solelyis hereby approved on a reviewnon-binding, advisory basis.
As an advisory vote, this proposal is not binding. The outcome of reports furnished tothis advisory vote does not overrule any decision by us or written representations from reporting persons, we believe all directors,our Board (or any committee thereof), create or imply any change to the fiduciary duties of us or our Board (or any committee thereof), or create or imply any additional fiduciary duties for us or our Board (or any committee thereof). However, our compensation committee and our Board value the opinions expressed by our stockholders in their vote on this proposal and will consider the outcome of the vote when making future compensation decisions for our named executive officers, and 10% owners timely filed all reports regarding transactions in the Company’s securities required to be filed for 2018 by Section 16(a) under the Exchange Act.officers.
Recommendation of our Board
OUR BOARD UNANIMOUSLY RECOMMENDS THAT STOCKHOLDERS VOTE FOR APPROVAL, ON A NON-BINDING, ADVISORY BASIS, OF THE COMPENSATION OF OUR NAMED EXECUTIVE OFFICERS.
32



PROPOSAL NO. 2—3 – RATIFICATION OF THE APPOINTMENT OF ERNST & YOUNG LLP
AS THE COMPANY’SOUR INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM FOR THE
FISCAL YEAR ENDING DECEMBER 31, 20182022
StockholdersWe are being askedasking stockholders to ratify the appointment by the audit committee of theour Board of Ernst &Young LLP as our independent registered public accounting firm.firm for the fiscal year ending December 31, 2022. Ernst & Young LLP has served as the company’sour independent registered public accounting firm since 2007.
The audit committee is solely responsible for selecting the Company’sour independent registered public accounting firm for the fiscal year ending December 31, 2018.firm. Stockholder approval is not required to appoint Ernst & Young LLP as our independent registered public accounting firm. However, theour Board believes that submitting the appointment of Ernst & Young LLP to the Stockholdersstockholders for ratification is good corporate governance. If stockholders do not ratify this appointment, the audit committee will reconsider whether to retain Ernst & Young LLP. If the selection of Ernst & Young LLP is ratified, the audit committee, in its discretion, may direct the appointment of a different independent registered public accounting firm at any time it decides that such a change would be in the best interestinterests of the CompanyConcert and itsour stockholders.
A representative of Ernst & Young LLP is expected to be present at the Annual Meeting and will have an opportunity to make a statement if he or she desires to do so and to respond to appropriate questions from our stockholders.

The following table summarizes the fees Ernst & Young LLP, our independent registered public accounting firm, billed to us for each of the last two fiscal years.
Fee Category20212020
Audit Fees (1)
$593,000$665,000
Tax Fees (2)
29,94468,910
All Other Fees (3)
2,1805,175
Total Fees$625,124$739,085
Fee Category 2018 2017
Audit Fees (1)
 $533,920
 $634,567
Tax Fees (2)
 25,000
 48,450
All Other Fees (3)
 5,055
 2,000
Total Fees $563,975
 $685,017

(1)Audit fees for 2018 and 2017Fees consist of fees for the audit of our consolidated financial statements, and the review of our interim financial statements.statements, consultations on accounting matters directly related to the audit and for comfort letter procedures in connection with financing activities.
(2)
Tax feesFees consist of fees incurred for tax compliance and tax return preparation.Tax fees for 2017 also include fees incurred in connection with preparation of an ownership analysis pursuant to Section 382 of the Internal Revenue Code to quantify any limitations on the availability of net operating loss carryforwards to offset taxable income.
(3)
All Other Fees represents paymentconsist of payments for access to the Ernst & Young LLP online accounting research database.
Pre-approval Policy and Procedures
The audit committee of our Board has adopted policies and procedures for the pre-approval of audit and non-audit services for the purposepurposes of maintaining the independence of our independent auditor. We may not engage our independent auditor to render any audit or non-audit service unless either the service is approved in advance by the audit committee, or the engagement to render the service is entered into pursuant to the audit committee’s pre-approval policies and procedures. Notwithstanding the foregoing, pre-approval is not required with respect to the provision of services, other than audit, review or attest services, by the independent auditor if the aggregate amount of all such services is no more than 5% of the total amount paid by us to the independent auditor during the fiscal year in which the services are provided, such services were not recognized by us at the time of the engagement to be non-audit services and such services are promptly brought to the attention of the audit committee and approved prior to completion of the audit by the audit committee.
From time to time, our audit committee may pre-approve services that are expected to be provided to us by the independent auditor during the following 12 months. At the time such pre-approval is granted, the audit committee must identify the particular pre-approved services in a sufficient level of detail so that our management will not be called upon to make a judgment as to whether a proposed service fits within the pre-approved services and, at each regularly
33



scheduled meeting of the audit committee following such approval, management or the independent auditor shall report to the audit committee regarding each service actually provided to us pursuant to such pre-approval.
During our 20182021 and 20172020 fiscal years, no services were provided to us by Ernst & Young LLP or any other accounting firm other than in accordance with the pre-approval policies and procedures described above.

Recommendation of theour Board
OUR BOARD UNANIMOUSLY RECOMMENDS THAT THE STOCKHOLDERS VOTE FOR THE RATIFICATION OF ERNST & YOUNG LLP AS OUR INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM.FIRM FOR THE FISCAL YEAR ENDING DECEMBER 31, 2022.

34

HOUSEHOLDING


Some banks, brokers
PROPOSAL NO. 4 – APPROVAL OF AN AMENDMENT TO OUR CERTIFICATE OF INCORPORATION TO INCREASE THE NUMBER OF AUTHORIZED SHARES OF COMMON STOCK
Background
Our authorized capital stock presently consists of 100,000,000 shares of common stock, par value $0.001 per share, and 5,000,000 shares of preferred stock, par value $0.001 per share. Our Board has adopted and is recommending that our stockholders approve a proposed amendment to our certificate of incorporation to increase the number of authorized shares of common stock from 100,000,000 to 200,000,000. The number of shares of preferred stock authorized for issuance would not be affected by the proposed amendment.
As of April 12, 2022, a total of:
36,329,342 shares of common stock were issued and outstanding;
1,861,273 shares of common stock were issuable upon the exercise of outstanding warrants;
12,621 shares of Series X1 preferred stock were issued and outstanding, which are convertible into 12,621,000 shares of common stock;
16,250 shares of Series X1 preferred stock were issuable upon the exercise of outstanding warrants, which are convertible into 16,250,000 shares of common stock;
5,048,014 shares of common stock were subject to outstanding stock options under the 2006 Plan and the 2014 Plan;
1,389,460 shares of common stock were subject to outstanding restricted stock units under the 2014 Plan; and
2,026,725 shares of common stock were reserved for future issuance under the 2014 Plan.
Accordingly, out of the 100,000,000 shares of common stock presently authorized, 75,525,814 shares of common stock are issued or reserved for issuance, and only 24,474,186 shares of common stock remain available for future issuance.
If stockholders approve the proposed amendment, the first paragraph of Article FOURTH of our certificate of incorporation will be deleted in its entirety and replaced by the following:
“FOURTH: The total number of shares of all classes of stock which the Corporation shall have authority to issue is 205,000,000 shares, consisting of (i) 200,000,000 shares of Common Stock, par value $0.001 per share (“Common Stock”), and (ii) 5,000,000 shares of Preferred Stock, par value $0.001 per share (“Preferred Stock”).”
The proposed amendment, if approved by our stockholders, would become effective upon the filing of an amendment to our certificate of incorporation with the Secretary of State of the State of Delaware, in the form of Appendix A hereto, or at the later time set forth in such amendment. Our Board reserves the right, notwithstanding stockholder approval and without further action by stockholders, to elect not to proceed with the proposed amendment if our Board determines that the proposed amendment is no longer in our best interests and the best interests of our stockholders.
If our stockholders approve the proposed amendment, subject to the discretion of our Board, we intend to file the amendment to our certificate of incorporation with the Secretary of State of the State of Delaware as soon as practicable after the Annual Meeting.
35



Reasons for the Proposed Increase
Over the past several years, we have used shares of our common stock to, among other things, engage in financings, compensate employees and for other general corporate purposes. The additional authorized shares of common stock permitted by the proposed amendment to our certificate of incorporation would allow us to continue to use common stock for purposes such as financings, providing equity incentives to our employees, officers or directors, business development activities and other nominee record holdersgeneral corporate purposes as our Board may be participating in the practiceapprove. Our Board believes that having a sufficient number of “householding” proxy statements and annual reports. This means that only one copyauthorized shares of our documents, including the annual reportcommon stock provides flexibility to stockholdersraise cash to carry out our overall strategy and proxy statementallows us to engage in strategic activities without using our cash. We do not currently have any specific plans, proposals or the Notice, may have been sent to multiple stockholders in your household. We will promptly deliver a separate copy of either document to you uponarrangements, written or oral, requestto issue any of the proposed additional authorized shares of common stock for general corporate or any other purposes. Unless required by applicable law or stock exchange rules, no further vote of the holders of common stock will be required.
Potential Effects of the Proposed Increase
The additional shares of common stock for which authorization is sought would be identical in powers, privileges and rights to the Company. Concert Pharmaceuticals, Inc. 65 Hayden Avenue, Suite 3000N, Lexington, MA 02421, Attention: Investor Relations, telephone: 781-860-0045. shares of common stock that are now authorized. Holders of common stock do not have preemptive rights to subscribe to additional securities that we may issue.
The issuance of additional shares of common stock would not affect the rights of stockholders of currently outstanding common stock, except for effects incidental to increasing the number of shares of common stock outstanding, such as, among other things, having a dilutive effect on earnings per share and on stockholders’ equity and voting rights. Furthermore, future sales of substantial amounts of our common stock, or the perception that these sales might occur, could adversely affect the prevailing market price of our common stock or limit our ability to raise additional capital. Stockholders should recognize that, as a result of this proposal, they will own a smaller percentage of our shares relative to the total number of authorized shares than they presently own.
Our Board has not proposed this increase in the number of authorized shares with the intention of discouraging tender offers or takeover attempts. However, the availability of additional authorized shares for issuance may have the effect of discouraging a merger, tender offer, proxy contest or other attempt to obtain control.
Effectiveness of Amendment
If you wantthe proposed amendment is adopted, it will become effective upon the filing of a certificate of amendment to receive separate copiesour certificate of incorporation with the Secretary of State of the Notice, proxy statement or annual report to stockholders in the future, or if you are receiving multiple copies and would like to receive only one copy per household, you should contact your bank, broker or other nominee record holder, or you may contact us at the above address and phone number.State of Delaware.



STOCKHOLDER PROPOSALS
A stockholder who would like to have a proposal considered for inclusion inRecommendation of our 2020 proxy statement must submit the proposal in accordance with the procedures outlined in Rule 14a-8 of the Exchange Act so that it is received by us no later than January 4, 2020, which is 120 days prior to the first anniversary of the mailing date of the Notice. However, if the date of the 2019 annual meeting of stockholders is changed by more than 30 days from the date of this year’s Annual Meeting, then the deadline is a reasonable time before we begin to print and send our proxy statement for the 2020 annual meeting of stockholders. SEC rules set standards for eligibility and specify the types of stockholder proposals that may be excluded from a proxy statement.Board
If a stockholder wishes to propose a nomination of persons for election to our Board or present a proposal at an annual meeting but does not wish to have the proposal considered for inclusion in our proxy statement and proxy card, our amended and restated bylaws establish an advance notice procedure for such nominations and proposals. Stockholders at an annual meeting may only consider proposals or nominations specified in the notice of meeting or brought before the meeting by or at the direction of the Board or by a stockholder of record on the record date for the meeting, who is entitled to vote at the meeting and who has delivered timely notice in proper form to our corporate secretary of the stockholder’s intention to bring such business before the meeting.OUR BOARD UNANIMOUSLY RECOMMENDS THAT STOCKHOLDERS VOTE FOR THE APPROVAL OF AN AMENDMENT TO OUR CERTIFICATE OF INCORPORATION TO INCREASE THE NUMBER OF AUTHORIZED SHARES OF COMMON STOCK.
The required notice must be in writing and received by our corporate secretary at our principal executive offices not less than 90 days nor more than 120 days prior to the first anniversary of the preceding year’s annual meeting. However, in the event that the date of the annual meeting is advanced by more than 20 days, or delayed by more than 60 days, from the first anniversary of the preceding year’s annual meeting, a stockholder’s notice must be so received no earlier than the 120th day prior to such annual meeting and not later than the close of business on the later of (A) the 90th day prior to such annual meeting and (B) the tenth day following the day on which notice of the date of such annual meeting was mailed or public disclosure of the date of such annual meeting was made, whichever first occurs. For stockholder proposals to be brought before the 2020 annual meeting of stockholders, the required notice must be received by our corporate secretary at our principal executive offices no earlier than February 14, 2020 and no later than March 15, 2020.
Stockholder proposals should be addressed to Concert Pharmaceuticals, Inc. 65 Hayden Avenue, Suite 3000N, Lexington, MA 02421, Attention: Corporate Secretary.
36


OTHER MATTERS
Our Board does not know of any other matters to be brought before the Annual Meeting. If any other matters not mentioned in this proxy statement are properly brought before the meeting, the individuals named in this proxy statement intend to use their discretionary voting authority under the proxy to vote the proxy in accordance with their best judgment on those matters.

Householding
proxycard2019finalpage1a01.jpgSome banks, brokers and other nominee record holders may be participating in the practice of “householding” proxy statements and annual reports. This means that only one copy of our proxy statement or annual report may have been sent to multiple stockholders in your household. We will promptly deliver a separate copy of either document to you upon written or oral request to Concert Pharmaceuticals, Inc., 65 Hayden Avenue, Suite 3000N, Lexington, MA 02421, Attention: Investor Relations, telephone: 781-860-0045. If you want to receive separate copies of our proxy statement or annual report in the future, or if you are receiving multiple copies and would like to receive only one copy per household, you should contact your bank, broker or other nominee record holder, or you may contact us at the above address and phone number.

Stockholder Proposals

A stockholder who would like to have a proposal considered for inclusion in our 2023 proxy statement must submit the proposal in accordance with the procedures outlined in Rule 14a-8 of the Exchange Act so that it is received by us no later than [_____], 2022, which is 120 days prior to the first anniversary of the mailing date of the Notice. However, if the date of our 2023 annual meeting of stockholders is changed by more than 30 days from the date of this year’s Annual Meeting, then the deadline is a reasonable time before we begin to print and send our proxy statement for our 2023 annual meeting of stockholders. SEC rules set standards for eligibility and specify the types of stockholder proposals that may be excluded from a proxy statement. To comply with the universal proxy rules (once effective), stockholders who intend to solicit proxies in support of director nominees other than the Company’s nominees must provide notice that sets forth the information required by Rule 14a-19 under the Securities Exchange Act of 1934 no later than April 10, 2023.
proxycard2019finalpage2.jpgIf a stockholder wishes to propose a nomination of persons for election to our Board or present a proposal at an annual meeting but does not wish to have the proposal considered for inclusion in our proxy statement and proxy card, our by-laws establish an advance notice procedure for such nominations and proposals. Stockholders at an annual meeting may only consider proposals or nominations specified in the notice of meeting or brought before the meeting by or at the direction of our Board or by a stockholder of record on the record date for the meeting, who is entitled to vote at the meeting and who has delivered timely notice in proper form to our corporate secretary of the stockholder’s intention to bring such business before the meeting.

The required notice must be in writing and received by our corporate secretary at our principal executive offices not less than 90 days nor more than 120 days prior to the first anniversary of the preceding year’s annual meeting. However, in the event that the date of the annual meeting is advanced by more than 20 days, or delayed by more than 60 days, from the first anniversary of the preceding year’s annual meeting, a stockholder’s notice must be so received no earlier than the 120th day prior to such annual meeting and not later than the close of business on the later of (A) the 90th day prior to such annual meeting and (B) the tenth day following the day on which notice of the date of such annual meeting was mailed or public disclosure of the date of such annual meeting was made, whichever first occurs. For stockholder proposals to be brought before our 2023 annual meeting of stockholders, assuming that the date of such annual meeting is not advanced by more than 20 days, or delayed by more than 60 days from the first anniversary of this year’s Annual Meeting, the required notice must be received by our corporate secretary at our principal executive offices no earlier than February 9, 2023 and no later than March 11, 2023.
Stockholder proposals should be addressed to Concert Pharmaceuticals, Inc., 65 Hayden Avenue, Suite 3000N, Lexington, MA 02421, Attention: Corporate Secretary.
40
37


Appendix A
CERTIFICATE OF AMENDMENT TO
RESTATED CERTIFICATE OF INCORPORATION
OF
CONCERT PHARMACEUTICALS, INC.
(Pursuant to Section 242 of the
Delaware General Corporation Law)
Concert Pharmaceuticals, Inc. (the “Corporation”), a corporation organized and existing under and by virtue of the provisions of the Delaware General Corporation Law (the “DGCL”), does hereby certify as follows:
A resolution was duly adopted by the Board of Directors of the Corporation pursuant to Section 242 of the DGCL setting forth a proposed amendment to the Restated Certificate of Incorporation of the Corporation and declaring said amendment to be advisable. The stockholders of the Corporation duly approved said proposed amendment in accordance with Section 242 of the DGCL. The resolution setting forth the amendment is as follows:
RESOLVED:    That the first paragraph of Article FOURTH of the Restated Certificate of Incorporation of the Corporation be and hereby is deleted in its entirety and the following is inserted in lieu thereof:
“FOURTH: The total number of shares of all classes of stock which the Corporation shall have authority to issue is 205,000,000 shares, consisting of (i) 200,000,000 shares of Common Stock, par value $0.001 per share (“Common Stock”), and (ii) 5,000,000 shares of Preferred Stock, par value $0.001 per share (“Preferred Stock”).”
***

A-1


IN WITNESS WHEREOF, this Certificate of Amendment has been executed by its duly authorized officer this ____ day of ________, 2022.
CONCERT PHARMACEUTICALS, INC.
By:
Name: Roger D. Tung
Title: President and Chief Executive Officer

A-2


proxycard_pagex1.jpg



proxycard_pagex2.jpg